1nz8: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:1nz8.jpg|left|200px]]<br /><applet load="1nz8" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="1nz8" />
-'''Solution Structure of the N-utilisation substance G (NusG) N-terminal (NGN) domain from Thermus thermophilus'''<br />
-==Overview==
+==Solution Structure of the N-utilization substance G (NusG) N-terminal (NGN) domain from Thermus thermophilus==
-NusG is an essential bacterial protein modulator of transcriptional, elongation and termination events, and interacts directly with RNA, polymerase and Rho protein. Found also in Archaea, NusG shows stretches of, sequence similarity to the eukaryotic transcription elongation factor, Spt5. Herein, the three-dimensional solution structure of the bacterial, NusG from Thermus thermophilus, which shows 43% amino acid sequence, similarity to the Escherichia coli NusG, is described, and a survey of, NusG and Spt5 amino acid sequences is presented. Although there is a clear, evolutionary and functional relationship between these proteins, it is, evident from the structural, sequence, and biochemical data that their, binding specificities to both nucleic acids and other proteins differ.
+<StructureSection load='1nz8' size='340' side='right'caption='[[1nz8]]' scene=''>
+== Structural highlights ==
-==About this Structure==
+<table><tr><td colspan='2'>[[1nz8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NZ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NZ8 FirstGlance]. <br>
-NZ8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1NZ8 OCA].
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nz8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nz8 OCA], [https://pdbe.org/1nz8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nz8 RCSB], [https://www.ebi.ac.uk/pdbsum/1nz8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nz8 ProSAT], [https://www.topsan.org/Proteins/RSGI/1nz8 TOPSAN]</span></td></tr>
-==Reference==
+</table>
-Structural and sequence comparisons arising from the solution structure of the transcription elongation factor NusG from Thermus thermophilus., Reay P, Yamasaki K, Terada T, Kuramitsu S, Shirouzu M, Yokoyama S, Proteins. 2004 Jul 1;56(1):40-51. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15162485 15162485]
+== Function ==
-[[Category: Single protein]]
+[https://www.uniprot.org/uniprot/NUSG_THET8 NUSG_THET8] Participates in transcription elongation, termination and antitermination (By similarity).
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nz/1nz8_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nz8 ConSurf].
+<div style="clear:both"></div>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Thermus thermophilus]]
-[[Category: Kuramitsu, S.]]
+[[Category: Kuramitsu S]]
-[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
+[[Category: Reay P]]
-[[Category: Reay, P.]]
+[[Category: Shirouzu M]]
-[[Category: Shirouzu, M.]]
+[[Category: Terada T]]
-[[Category: Terada, T.]]
+[[Category: Yamasaki K]]
-[[Category: Yamasaki, K.]]
+[[Category: Yokoyama S]]
-[[Category: Yokoyama, S.]]
-[[Category: antitermination]]
-[[Category: riken structural genomics/proteomics initiative]]
-[[Category: rsgi]]
-[[Category: structural genomics]]
-[[Category: termination]]
-[[Category: transcription elongation]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 22:40:51 2007''