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==Solution Structure of the N-utilization substance G (NusG) N-terminal (NGN) domain from Thermus thermophilus==
==Solution Structure of the N-utilization substance G (NusG) N-terminal (NGN) domain from Thermus thermophilus==
<StructureSection load='1nz8' size='340' side='right' caption='[[1nz8]], [[NMR_Ensembles_of_Models | 31 NMR models]]' scene=''>
<StructureSection load='1nz8' size='340' side='right'caption='[[1nz8]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1nz8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"flavobacterium_thermophilum"_yoshida_and_oshima_1971 "flavobacterium thermophilum" yoshida and oshima 1971]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NZ8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NZ8 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1nz8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NZ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NZ8 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1nz9|1nz9]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NusG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 "Flavobacterium thermophilum" Yoshida and Oshima 1971])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nz8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nz8 OCA], [https://pdbe.org/1nz8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nz8 RCSB], [https://www.ebi.ac.uk/pdbsum/1nz8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nz8 ProSAT], [https://www.topsan.org/Proteins/RSGI/1nz8 TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nz8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nz8 OCA], [http://pdbe.org/1nz8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1nz8 RCSB], [http://www.ebi.ac.uk/pdbsum/1nz8 PDBsum], [http://www.topsan.org/Proteins/RSGI/1nz8 TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/NUSG_THET8 NUSG_THET8]] Participates in transcription elongation, termination and antitermination (By similarity).  
[https://www.uniprot.org/uniprot/NUSG_THET8 NUSG_THET8] Participates in transcription elongation, termination and antitermination (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nz/1nz8_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nz/1nz8_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
Line 19: Line 19:
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nz8 ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nz8 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
NusG is an essential bacterial protein modulator of transcriptional elongation and termination events, and interacts directly with RNA polymerase and Rho protein. Found also in Archaea, NusG shows stretches of sequence similarity to the eukaryotic transcription elongation factor Spt5. Herein, the three-dimensional solution structure of the bacterial NusG from Thermus thermophilus, which shows 43% amino acid sequence similarity to the Escherichia coli NusG, is described, and a survey of NusG and Spt5 amino acid sequences is presented. Although there is a clear evolutionary and functional relationship between these proteins, it is evident from the structural, sequence, and biochemical data that their binding specificities to both nucleic acids and other proteins differ.
Structural and sequence comparisons arising from the solution structure of the transcription elongation factor NusG from Thermus thermophilus.,Reay P, Yamasaki K, Terada T, Kuramitsu S, Shirouzu M, Yokoyama S Proteins. 2004 Jul 1;56(1):40-51. PMID:15162485<ref>PMID:15162485</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1nz8" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Flavobacterium thermophilum yoshida and oshima 1971]]
[[Category: Large Structures]]
[[Category: Kuramitsu, S]]
[[Category: Thermus thermophilus]]
[[Category: Structural genomic]]
[[Category: Kuramitsu S]]
[[Category: Reay, P]]
[[Category: Reay P]]
[[Category: Shirouzu, M]]
[[Category: Shirouzu M]]
[[Category: Terada, T]]
[[Category: Terada T]]
[[Category: Yamasaki, K]]
[[Category: Yamasaki K]]
[[Category: Yokoyama, S]]
[[Category: Yokoyama S]]
[[Category: Antitermination]]
[[Category: Rsgi]]
[[Category: Termination]]
[[Category: Transcription]]
[[Category: Transcription elongation]]

Latest revision as of 11:54, 10 April 2024

Solution Structure of the N-utilization substance G (NusG) N-terminal (NGN) domain from Thermus thermophilusSolution Structure of the N-utilization substance G (NusG) N-terminal (NGN) domain from Thermus thermophilus

Structural highlights

1nz8 is a 1 chain structure with sequence from Thermus thermophilus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

NUSG_THET8 Participates in transcription elongation, termination and antitermination (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Drag the structure with the mouse to rotate

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OCA
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