1n4y: Difference between revisions

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-{{Seed}}
-[[Image:1n4y.png|left|200px]]
-<!--
+==REFINED STRUCTURE OF KISTRIN==
-The line below this paragraph, containing "STRUCTURE_1n4y", creates the "Structure Box" on the page.
+<StructureSection load='1n4y' size='340' side='right'caption='[[1n4y]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1n4y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Calloselasma_rhodostoma Calloselasma rhodostoma]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1kst 1kst]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N4Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N4Y FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n4y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n4y OCA], [https://pdbe.org/1n4y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n4y RCSB], [https://www.ebi.ac.uk/pdbsum/1n4y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n4y ProSAT]</span></td></tr>
-{{STRUCTURE_1n4y|  PDB=1n4y  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/VM2RH_CALRH VM2RH_CALRH] Metalloproteinase rhodostoxin: snake venom metalloproteinase that impairs hemostasis in the envenomed animal (By similarity).  Disintegrin rhodostomin: inhibit platelet aggregation induced by ADP, thrombin, platelet-activating factor and collagen. Acts by inhibiting fibrinogen interaction with platelet receptors GPIIb/GPIIIa (ITGA2B/ITGB3).
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n4/1n4y_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n4y ConSurf].
+<div style="clear:both"></div>
-===REFINED STRUCTURE OF KISTRIN===
+==See Also==
+*[[Disintegrin|Disintegrin]]
+__TOC__
-<!--
+</StructureSection>
-The line below this paragraph, {{ABSTRACT_PUBMED_1862345}}, adds the Publication Abstract to the page
-(as it appears on PubMed at http://www.pubmed.gov), where 1862345 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_1862345}}
-==About this Structure==
-N4Y is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Calloselasma_rhodostoma Calloselasma rhodostoma]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1kst 1kst]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N4Y OCA].
-==Reference==
-Solution structure of kistrin, a potent platelet aggregation inhibitor and GP IIb-IIIa antagonist., Adler M, Lazarus RA, Dennis MS, Wagner G, Science. 1991 Jul 26;253(5018):445-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1862345 1862345]
 [[Category: Calloselasma rhodostoma]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Dennis, M S.]]
+[[Category: Dennis MS]]
-[[Category: Krane, J.]]
+[[Category: Krane J]]
-[[Category: Krezel, A M.]]
+[[Category: Krezel AM]]
-[[Category: Lazarus, R A.]]
+[[Category: Lazarus RA]]
-[[Category: Wagner, G.]]
+[[Category: Wagner G]]
-[[Category: Beta]]
-[[Category: Blood coagulation]]
-[[Category: Rgd]]
-[[Category: Venom]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:24:07 2008''