1mq8: Difference between revisions

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-{{Seed}}
-[[Image:1mq8.png|left|200px]]
-<!--
+==Crystal structure of alphaL I domain in complex with ICAM-1==
-The line below this paragraph, containing "STRUCTURE_1mq8", creates the "Structure Box" on the page.
+<StructureSection load='1mq8' size='340' side='right'caption='[[1mq8]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1mq8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MQ8 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-{{STRUCTURE_1mq8|  PDB=1mq8  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mq8 OCA], [https://pdbe.org/1mq8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mq8 RCSB], [https://www.ebi.ac.uk/pdbsum/1mq8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mq8 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ICAM1_HUMAN ICAM1_HUMAN] ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.<ref>PMID:2538243</ref> <ref>PMID:1968231</ref> <ref>PMID:11173916</ref> <ref>PMID:17875742</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mq/1mq8_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mq8 ConSurf].
+<div style="clear:both"></div>
-===Crystal structure of alphaL I domain in complex with ICAM-1===
+==See Also==
+*[[Integrin 3D structures|Integrin 3D structures]]
+*[[Intercellular adhesion molecule|Intercellular adhesion molecule]]
-<!--
+== References ==
-The line below this paragraph, {{ABSTRACT_PUBMED_12526797}}, adds the Publication Abstract to the page
+<references/>
-(as it appears on PubMed at http://www.pubmed.gov), where 12526797 is the PubMed ID number.
+__TOC__
--->
+</StructureSection>
-{{ABSTRACT_PUBMED_12526797}}
-==About this Structure==
-MQ8 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQ8 OCA].
-==Reference==
-Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation., Shimaoka M, Xiao T, Liu JH, Yang Y, Dong Y, Jun CD, McCormack A, Zhang R, Joachimiak A, Takagi J, Wang JH, Springer TA, Cell. 2003 Jan 10;112(1):99-111. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12526797 12526797]
 [[Category: Homo sapiens]]
-[[Category: Protein complex]]
+[[Category: Large Structures]]
-[[Category: Dong, Y.]]
+[[Category: Dong Y]]
-[[Category: Joachimiak, A.]]
+[[Category: Joachimiak A]]
-[[Category: Jun, C D.]]
+[[Category: Jun C-D]]
-[[Category: Liu, J H.]]
+[[Category: Liu J-H]]
-[[Category: McCormack, A.]]
+[[Category: McCormack A]]
-[[Category: Shimaoka, M.]]
+[[Category: Shimaoka M]]
-[[Category: Springer, T A.]]
+[[Category: Springer TA]]
-[[Category: Takagi, J.]]
+[[Category: Takagi J]]
-[[Category: Wang, J H.]]
+[[Category: Wang J-H]]
-[[Category: Xiao, T.]]
+[[Category: Xiao T]]
-[[Category: Yang, Y.]]
+[[Category: Yang Y]]
-[[Category: Zhang, R.]]
+[[Category: Zhang R]]
-[[Category: Ig superfamily]]
-[[Category: Metal mediated protein interface]]
-[[Category: Rossmann fold]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul  3 00:51:41 2008''