1mcx: Difference between revisions

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-[[Image:1mcx.png|left|200px]]
-{{STRUCTURE_1mcx|  PDB=1mcx  |  SCENE=  }}
+==STRUCTURE OF FULL-LENGTH ANNEXIN A1 IN THE PRESENCE OF CALCIUM==
+<StructureSection load='1mcx' size='340' side='right'caption='[[1mcx]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
-===STRUCTURE OF FULL-LENGTH ANNEXIN A1 IN THE PRESENCE OF CALCIUM===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1mcx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MCX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MCX FirstGlance]. <br>
-{{ABSTRACT_PUBMED_12595246}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.03&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mcx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mcx OCA], [https://pdbe.org/1mcx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mcx RCSB], [https://www.ebi.ac.uk/pdbsum/1mcx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mcx ProSAT]</span></td></tr>
-[[1mcx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MCX OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ANXA1_PIG ANXA1_PIG] Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mc/1mcx_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mcx ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Annexin|Annexin]]
+*[[Annexin 3D structures|Annexin 3D structures]]
+__TOC__
-==Reference==
+</StructureSection>
-<ref group="xtra">PMID:012595246</ref><references group="xtra"/>
+[[Category: Large Structures]]
 [[Category: Sus scrofa]]
-[[Category: Luecke, H.]]
+[[Category: Luecke H]]
-[[Category: Rosengarth, A.]]
+[[Category: Rosengarth A]]
-[[Category: Calcium/phospholipid binding protein]]
-[[Category: Metal binding protein]]