1lk3: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1lk3.png|left|200px]]
-{{STRUCTURE_1lk3|  PDB=1lk3  |  SCENE=  }}
+==ENGINEERED HUMAN INTERLEUKIN-10 MONOMER COMPLEXED TO 9D7 FAB FRAGMENT==
+<StructureSection load='1lk3' size='340' side='right'caption='[[1lk3]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
-===ENGINEERED HUMAN INTERLEUKIN-10 MONOMER COMPLEXED TO 9D7 FAB FRAGMENT===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1lk3]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LK3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LK3 FirstGlance]. <br>
-{{ABSTRACT_PUBMED_12121653}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.91&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lk3 OCA], [https://pdbe.org/1lk3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lk3 RCSB], [https://www.ebi.ac.uk/pdbsum/1lk3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lk3 ProSAT]</span></td></tr>
-==About this Structure==
+</table>
-[[1lk3]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LK3 OCA].
+== Function ==
+[https://www.uniprot.org/uniprot/IL10_HUMAN IL10_HUMAN] Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lk/1lk3_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lk3 ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Interleukin|Interleukin]]
+*[[Interleukin 3D structures|Interleukin 3D structures]]
+__TOC__
-==Reference==
+</StructureSection>
-<ref group="xtra">PMID:012121653</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
+[[Category: Large Structures]]
 [[Category: Rattus norvegicus]]
-[[Category: DiGiacomo, R.]]
+[[Category: DiGiacomo R]]
-[[Category: Indelicato, S R.]]
+[[Category: Indelicato SR]]
-[[Category: Jones, B C.]]
+[[Category: Jones BC]]
-[[Category: Josephson, K.]]
+[[Category: Josephson K]]
-[[Category: Walter, L J.]]
+[[Category: Walter LJ]]
-[[Category: Walter, M R.]]
+[[Category: Walter MR]]
-[[Category: Antigen-antibody complex]]
-[[Category: Immune system]]