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[[Image:1klv.gif|left|200px]]


{{Structure
==Solution Structure and Backbone Dynamics of GABARAP, GABAA Receptor associated protein==
|PDB= 1klv |SIZE=350|CAPTION= <scene name='initialview01'>1klv</scene>
<StructureSection load='1klv' size='340' side='right'caption='[[1klv]]' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[1klv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KLV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KLV FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
|GENE=  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1klv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1klv OCA], [https://pdbe.org/1klv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1klv RCSB], [https://www.ebi.ac.uk/pdbsum/1klv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1klv ProSAT]</span></td></tr>
}}
</table>
== Function ==
[https://www.uniprot.org/uniprot/GBRAP_HUMAN GBRAP_HUMAN] May play a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy (By similarity).<ref>PMID:15977068</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kl/1klv_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1klv ConSurf].
<div style="clear:both"></div>


'''Solution Structure and Backbone Dynamics of GABARAP, GABAA Receptor associated protein'''
==See Also==
 
*[[GABA receptor-associated protein 3D structures|GABA receptor-associated protein 3D structures]]
 
== References ==
==About this Structure==
<references/>
1KLV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KLV OCA].
__TOC__
 
</StructureSection>
==Reference==
1H, 13C and '5N resonance assignments of GABARAP, GABAA receptor associated protein., Kouno T, Miura K, Kanematsu T, Shirakawa M, Hirata M, Kawano K, J Biomol NMR. 2002 Jan;22(1):97-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11885988 11885988]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Hirata, M.]]
[[Category: Hirata M]]
[[Category: Kanematsu, T.]]
[[Category: Kanematsu T]]
[[Category: Kawano, K.]]
[[Category: Kawano K]]
[[Category: Kouno, T.]]
[[Category: Kouno T]]
[[Category: Miura, K.]]
[[Category: Miura K]]
[[Category: Shirakawa, M.]]
[[Category: Shirakawa M]]
[[Category: Tada, M.]]
[[Category: Tada M]]
[[Category: Tate, S.]]
[[Category: Tate S]]
[[Category: ubiquitin-like fold]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:19:13 2008''

Latest revision as of 11:01, 3 April 2024

Solution Structure and Backbone Dynamics of GABARAP, GABAA Receptor associated proteinSolution Structure and Backbone Dynamics of GABARAP, GABAA Receptor associated protein

Structural highlights

1klv is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GBRAP_HUMAN May play a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy (By similarity).[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Lee JH, Rho SB, Chun T. GABAA receptor-associated protein (GABARAP) induces apoptosis by interacting with DEAD (Asp-Glu-Ala-Asp/His) box polypeptide 47 (DDX 47). Biotechnol Lett. 2005 May;27(9):623-8. PMID:15977068 doi:http://dx.doi.org/10.1007/s10529-005-3628-2
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