1j8k: Difference between revisions

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-[[Image:1j8k.jpg|left|200px]]<br /><applet load="1j8k" size="350" color="white" frame="true" align="right" spinBox="true"
-caption="1j8k" />
-'''NMR STRUCTURE OF THE FIBRONECTIN EDA DOMAIN, NMR, 20 STRUCTURES'''<br />
-==Disease==
+==NMR STRUCTURE OF THE FIBRONECTIN EDA DOMAIN, NMR, 20 STRUCTURES==
-Known diseases associated with this structure: Ehlers-Danlos syndrome, type X, 225310 (1) OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=135600 135600]]
+<StructureSection load='1j8k' size='340' side='right'caption='[[1j8k]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1j8k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J8K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1J8K FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1j8k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j8k OCA], [https://pdbe.org/1j8k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1j8k RCSB], [https://www.ebi.ac.uk/pdbsum/1j8k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1j8k ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/FINC_HUMAN FINC_HUMAN] Defects in FN1 are the cause of glomerulopathy with fibronectin deposits type 2 (GFND2) [MIM:[https://omim.org/entry/601894 601894]; also known as familial glomerular nephritis with fibronectin deposits or fibronectin glomerulopathy. GFND is a genetically heterogeneous autosomal dominant disorder characterized clinically by proteinuria, microscopic hematuria, and hypertension that leads to end-stage renal failure in the second to fifth decade of life.<ref>PMID:18268355</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/FINC_HUMAN FINC_HUMAN] Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape.<ref>PMID:8114919</ref> <ref>PMID:11209058</ref> <ref>PMID:15665290</ref> <ref>PMID:19379667</ref>   Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.<ref>PMID:8114919</ref> <ref>PMID:11209058</ref> <ref>PMID:15665290</ref> <ref>PMID:19379667</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j8/1j8k_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1j8k ConSurf].
+<div style="clear:both"></div>
-==About this Structure==
+==See Also==
-J8K is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J8K OCA].
+*[[Fibronectin 3D structures|Fibronectin 3D structures]]
+== References ==
-==Reference==
+<references/>
-NMR structure of human fibronectin EDA., Niimi T, Osawa M, Yamaji N, Yasunaga K, Sakashita H, Mase T, Tanaka A, Fujita S, J Biomol NMR. 2001 Nov;21(3):281-4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11775745 11775745]
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Fujita, S.]]
+[[Category: Fujita S]]
-[[Category: Mase, T.]]
+[[Category: Mase T]]
-[[Category: Niimi, T.]]
+[[Category: Niimi T]]
-[[Category: Osawa, M.]]
+[[Category: Osawa M]]
-[[Category: Sakashita, H.]]
+[[Category: Sakashita H]]
-[[Category: Tanaka, A.]]
+[[Category: Tanaka A]]
-[[Category: Yamaji, N.]]
+[[Category: Yamaji N]]
-[[Category: Yasunaga, K.]]
+[[Category: Yasunaga K]]
-[[Category: eda]]
-[[Category: fibronectin]]
-[[Category: protein binding]]
-[[Category: typeiii domain]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:06:11 2008''