1j7u: Difference between revisions

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-[[Image:1j7u.png|left|200px]]
-{{STRUCTURE_1j7u|  PDB=1j7u  |  SCENE=  }}
+==Crystal Structure of 3',5"-Aminoglycoside Phosphotransferase Type IIIa AMPPNP Complex==
+<StructureSection load='1j7u' size='340' side='right'caption='[[1j7u]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-===Crystal Structure of 3',5"-Aminoglycoside Phosphotransferase Type IIIa AMPPNP Complex===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1j7u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J7U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1J7U FirstGlance]. <br>
-{{ABSTRACT_PUBMED_11467935}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1j7u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j7u OCA], [https://pdbe.org/1j7u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1j7u RCSB], [https://www.ebi.ac.uk/pdbsum/1j7u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1j7u ProSAT]</span></td></tr>
-[[1j7u]] is a 2 chain structure of [[Phosphotransferase]] with sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J7U OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/KKA3_ENTFL KKA3_ENTFL] Resistance to kanamycin and structurally-related aminoglycosides, including amikacin.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j7/1j7u_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1j7u ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Phosphotransferase|Phosphotransferase]]
+*[[Phosphotransferase 3D structures|Phosphotransferase 3D structures]]
+__TOC__
-==Reference==
+</StructureSection>
-<ref group="xtra">PMID:011467935</ref><references group="xtra"/>
 [[Category: Enterococcus faecalis]]
-[[Category: Kanamycin kinase]]
+[[Category: Large Structures]]
-[[Category: Berghuis, A M.]]
+[[Category: Berghuis AM]]
-[[Category: Burk, D L.]]
+[[Category: Burk DL]]
-[[Category: Hon, W C.]]
+[[Category: Hon WC]]
-[[Category: Leung, A K.W.]]
+[[Category: Leung AK-W]]
-[[Category: Antibiotic resistance]]
-[[Category: Atp-binding]]
-[[Category: Kinase]]
-[[Category: Transferase]]