1iob: Difference between revisions

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[[Image:1iob.png|left|200px]]


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==INTERLEUKIN-1 BETA FROM JOINT X-RAY AND NMR REFINEMENT==
The line below this paragraph, containing "STRUCTURE_1iob", creates the "Structure Box" on the page.
<StructureSection load='1iob' size='340' side='right'caption='[[1iob]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1iob]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IOB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IOB FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Hybrid , Solution NMR , X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1iob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iob OCA], [https://pdbe.org/1iob PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1iob RCSB], [https://www.ebi.ac.uk/pdbsum/1iob PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1iob ProSAT]</span></td></tr>
{{STRUCTURE_1iob| PDB=1iob |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/IL1B_HUMAN IL1B_HUMAN] Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.<ref>PMID:3920526</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/io/1iob_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1iob ConSurf].
<div style="clear:both"></div>


===INTERLEUKIN-1 BETA FROM JOINT X-RAY AND NMR REFINEMENT===
==See Also==
 
*[[Interleukin 3D structures|Interleukin 3D structures]]
 
== References ==
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{{ABSTRACT_PUBMED_1502561}}
 
==About this Structure==
1IOB is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IOB OCA].
 
==Reference==
<ref group="xtra">PMID:1502561</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Clore, G M.]]
[[Category: Large Structures]]
[[Category: Shaanan, B.]]
[[Category: Clore GM]]
[[Category: Cytokine]]
[[Category: Shaanan B]]
[[Category: Inflammatory response]]
[[Category: Macrophage]]
[[Category: Mitogen]]
[[Category: Pyrogen]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 04:51:53 2009''

Latest revision as of 10:48, 3 April 2024

INTERLEUKIN-1 BETA FROM JOINT X-RAY AND NMR REFINEMENTINTERLEUKIN-1 BETA FROM JOINT X-RAY AND NMR REFINEMENT

Structural highlights

1iob is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Hybrid , Solution NMR , X-ray diffraction, Resolution 2Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

IL1B_HUMAN Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Van Damme J, De Ley M, Opdenakker G, Billiau A, De Somer P, Van Beeumen J. Homogeneous interferon-inducing 22K factor is related to endogenous pyrogen and interleukin-1. Nature. 1985 Mar 21-27;314(6008):266-8. PMID:3920526

1iob, resolution 2.00Å

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