1iob: Difference between revisions

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[[Image:1iob.gif|left|200px]]


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==INTERLEUKIN-1 BETA FROM JOINT X-RAY AND NMR REFINEMENT==
The line below this paragraph, containing "STRUCTURE_1iob", creates the "Structure Box" on the page.
<StructureSection load='1iob' size='340' side='right'caption='[[1iob]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1iob]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IOB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IOB FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Hybrid , Solution NMR , X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1iob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iob OCA], [https://pdbe.org/1iob PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1iob RCSB], [https://www.ebi.ac.uk/pdbsum/1iob PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1iob ProSAT]</span></td></tr>
{{STRUCTURE_1iob| PDB=1iob |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/IL1B_HUMAN IL1B_HUMAN] Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.<ref>PMID:3920526</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/io/1iob_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1iob ConSurf].
<div style="clear:both"></div>


'''INTERLEUKIN-1 BETA FROM JOINT X-RAY AND NMR REFINEMENT'''
==See Also==
 
*[[Interleukin 3D structures|Interleukin 3D structures]]
 
== References ==
==Overview==
<references/>
Joint refinement of macromolecules against crystallographic and nuclear magnetic resonance (NMR) observations is presented as a way of combining experimental information from the two methods. The model of interleukin-1 beta derived by the joint x-ray and NMR refinement is shown to be consistent with the experimental observations of both methods and to have crystallographic R value and geometrical parameters that are of the same quality as or better than those of models obtained by conventional crystallographic studies. The few NMR observations that are violated by the model serve as an indicator for genuine differences between the crystal and solution structures. The joint x-ray-NMR refinement can resolve structural ambiguities encountered in studies of multidomain proteins, in which low- to medium-resolution diffraction data can be complemented by higher resolution NMR data obtained for the individual domains.
__TOC__
 
</StructureSection>
==About this Structure==
1IOB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IOB OCA].
 
==Reference==
Combining experimental information from crystal and solution studies: joint X-ray and NMR refinement., Shaanan B, Gronenborn AM, Cohen GH, Gilliland GL, Veerapandian B, Davies DR, Clore GM, Science. 1992 Aug 14;257(5072):961-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1502561 1502561]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Clore, G M.]]
[[Category: Clore GM]]
[[Category: Shaanan, B.]]
[[Category: Shaanan B]]
[[Category: Cytokine]]
[[Category: Inflammatory response]]
[[Category: Macrophage]]
[[Category: Mitogen]]
[[Category: Pyrogen]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 20:12:58 2008''

Latest revision as of 10:48, 3 April 2024

INTERLEUKIN-1 BETA FROM JOINT X-RAY AND NMR REFINEMENTINTERLEUKIN-1 BETA FROM JOINT X-RAY AND NMR REFINEMENT

Structural highlights

1iob is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Hybrid , Solution NMR , X-ray diffraction, Resolution 2Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

IL1B_HUMAN Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Van Damme J, De Ley M, Opdenakker G, Billiau A, De Somer P, Van Beeumen J. Homogeneous interferon-inducing 22K factor is related to endogenous pyrogen and interleukin-1. Nature. 1985 Mar 21-27;314(6008):266-8. PMID:3920526

1iob, resolution 2.00Å

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