1i9b: Difference between revisions

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[[Image:1i9b.gif|left|200px]]


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==X-RAY STRUCTURE OF ACETYLCHOLINE BINDING PROTEIN (ACHBP)==
The line below this paragraph, containing "STRUCTURE_1i9b", creates the "Structure Box" on the page.
<StructureSection load='1i9b' size='340' side='right'caption='[[1i9b]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1i9b]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Lymnaea_stagnalis Lymnaea stagnalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I9B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1I9B FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
{{STRUCTURE_1i9b| PDB=1i9b |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1i9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i9b OCA], [https://pdbe.org/1i9b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1i9b RCSB], [https://www.ebi.ac.uk/pdbsum/1i9b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1i9b ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ACHP_LYMST ACHP_LYMST] Binds to acetylcholine. Modulates neuronal synaptic transmission.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i9/1i9b_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1i9b ConSurf].
<div style="clear:both"></div>


'''X-RAY STRUCTURE OF ACETYLCHOLINE BINDING PROTEIN (ACHBP)'''
==See Also==
 
*[[Acetylcholine binding protein 3D structures|Acetylcholine binding protein 3D structures]]
 
__TOC__
==Overview==
</StructureSection>
Pentameric ligand gated ion-channels, or Cys-loop receptors, mediate rapid chemical transmission of signals. This superfamily of allosteric transmembrane proteins includes the nicotinic acetylcholine (nAChR), serotonin 5-HT3, gamma-aminobutyric-acid (GABAA and GABAC) and glycine receptors. Biochemical and electrophysiological information on the prototypic nAChRs is abundant but structural data at atomic resolution have been missing. Here we present the crystal structure of molluscan acetylcholine-binding protein (AChBP), a structural and functional homologue of the amino-terminal ligand-binding domain of an nAChR alpha-subunit. In the AChBP homopentamer, the protomers have an immunoglobulin-like topology. Ligand-binding sites are located at each of five subunit interfaces and contain residues contributed by biochemically determined 'loops' A to F. The subunit interfaces are highly variable within the ion-channel family, whereas the conserved residues stabilize the protomer fold. This AChBP structure is relevant for the development of drugs against, for example, Alzheimer's disease and nicotine addiction.
[[Category: Large Structures]]
 
==About this Structure==
1I9B is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Lymnaea_stagnalis Lymnaea stagnalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I9B OCA].
 
==Reference==
Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors., Brejc K, van Dijk WJ, Klaassen RV, Schuurmans M, van Der Oost J, Smit AB, Sixma TK, Nature. 2001 May 17;411(6835):269-76. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11357122 11357122]
[[Category: Lymnaea stagnalis]]
[[Category: Lymnaea stagnalis]]
[[Category: Single protein]]
[[Category: Brejc K]]
[[Category: Brejc, K.]]
[[Category: Klaassen R]]
[[Category: Dijk, W J.van.]]
[[Category: Schuurmans M]]
[[Category: Klaassen, R.]]
[[Category: Sixma TK]]
[[Category: Oost, J van der.]]
[[Category: Smit AB]]
[[Category: Schuurmans, M.]]
[[Category: Van Dijk WJ]]
[[Category: Sixma, T K.]]
[[Category: Van der Oost J]]
[[Category: Smit, A B.]]
[[Category: Igg fold]]
[[Category: Pentamer]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 19:43:57 2008''

Latest revision as of 10:45, 3 April 2024

X-RAY STRUCTURE OF ACETYLCHOLINE BINDING PROTEIN (ACHBP)X-RAY STRUCTURE OF ACETYLCHOLINE BINDING PROTEIN (ACHBP)

Structural highlights

1i9b is a 5 chain structure with sequence from Lymnaea stagnalis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.7Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ACHP_LYMST Binds to acetylcholine. Modulates neuronal synaptic transmission.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1i9b, resolution 2.70Å

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OCA
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