1i2k: Difference between revisions

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<StructureSection load='1i2k' size='340' side='right'caption='[[1i2k]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
<StructureSection load='1i2k' size='340' side='right'caption='[[1i2k]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1i2k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I2K OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1I2K FirstGlance]. <br>
<table><tr><td colspan='2'>[[1i2k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I2K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1I2K FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.79&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PABC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1i2k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i2k OCA], [http://pdbe.org/1i2k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1i2k RCSB], [http://www.ebi.ac.uk/pdbsum/1i2k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1i2k ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1i2k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i2k OCA], [https://pdbe.org/1i2k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1i2k RCSB], [https://www.ebi.ac.uk/pdbsum/1i2k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1i2k ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PABC_ECOLI PABC_ECOLI]] Involved in the biosynthesis of p-aminobenzoate (PABA), a precursor of tetrahydrofolate. Converts 4-amino-4-deoxychorismate into 4-aminobenzoate (PABA) and pyruvate.<ref>PMID:1644759</ref> <ref>PMID:2251281</ref>
[https://www.uniprot.org/uniprot/PABC_ECOLI PABC_ECOLI] Involved in the biosynthesis of p-aminobenzoate (PABA), a precursor of tetrahydrofolate. Converts 4-amino-4-deoxychorismate into 4-aminobenzoate (PABA) and pyruvate.<ref>PMID:1644759</ref> <ref>PMID:2251281</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus coli migula 1895]]
[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Eisenstein, E]]
[[Category: Eisenstein E]]
[[Category: Fisher, K E]]
[[Category: Fisher KE]]
[[Category: Howard, A J]]
[[Category: Howard AJ]]
[[Category: Jensen, P Y]]
[[Category: Jensen PY]]
[[Category: Ladner, J E]]
[[Category: Ladner JE]]
[[Category: Pachikara, A S]]
[[Category: Pachikara AS]]
[[Category: Parsons, J F]]
[[Category: Parsons JF]]
[[Category: Tordova, M]]
[[Category: Tordova M]]
[[Category: Aminodeoxychorismate]]
[[Category: Lyase]]
[[Category: Pabc]]
[[Category: Pyridoxal phosphate]]

Latest revision as of 10:44, 3 April 2024

AMINODEOXYCHORISMATE LYASE FROM ESCHERICHIA COLIAMINODEOXYCHORISMATE LYASE FROM ESCHERICHIA COLI

Structural highlights

1i2k is a 1 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.79Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PABC_ECOLI Involved in the biosynthesis of p-aminobenzoate (PABA), a precursor of tetrahydrofolate. Converts 4-amino-4-deoxychorismate into 4-aminobenzoate (PABA) and pyruvate.[1] [2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Green JM, Merkel WK, Nichols BP. Characterization and sequence of Escherichia coli pabC, the gene encoding aminodeoxychorismate lyase, a pyridoxal phosphate-containing enzyme. J Bacteriol. 1992 Aug;174(16):5317-23. PMID:1644759
  2. ↑ Ye QZ, Liu J, Walsh CT. p-Aminobenzoate synthesis in Escherichia coli: purification and characterization of PabB as aminodeoxychorismate synthase and enzyme X as aminodeoxychorismate lyase. Proc Natl Acad Sci U S A. 1990 Dec;87(23):9391-5. PMID:2251281

1i2k, resolution 1.79Å

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