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New page: '''Unreleased structure''' The entry 8deg is ON HOLD Authors: Srivastava, A., Lexa, K., de Vicente, J. Description: Crystal structure of DLK in complex with inhibitor DN0011197 [[Categ... |
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==Crystal structure of DLK in complex with inhibitor DN0011197== | |||
<StructureSection load='8deg' size='340' side='right'caption='[[8deg]], [[Resolution|resolution]] 2.79Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8deg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DEG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DEG FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.79Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SIQ:methyl+(1S,4S)-5-{(4P)-4-[5-amino-6-(difluoromethoxy)pyrazin-2-yl]-6-[(1R,4R)-2-azabicyclo[2.1.1]hexan-2-yl]pyridin-2-yl}-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate'>SIQ</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8deg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8deg OCA], [https://pdbe.org/8deg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8deg RCSB], [https://www.ebi.ac.uk/pdbsum/8deg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8deg ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/M3K12_HUMAN M3K12_HUMAN] May be an activator of the JNK/SAPK pathway. Phosphorylates beta-casein, histone 1 and myelin basic protein in vitro. | |||
==See Also== | |||
*[[Mitogen-activated protein kinase kinase kinase|Mitogen-activated protein kinase kinase kinase]] | |||
__TOC__ | |||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Lexa | [[Category: Large Structures]] | ||
[[Category: Srivastava | [[Category: Lexa K]] | ||
[[Category: Srivastava A]] | |||
[[Category: De Vicente J]] | |||
Latest revision as of 10:25, 3 April 2024
Crystal structure of DLK in complex with inhibitor DN0011197Crystal structure of DLK in complex with inhibitor DN0011197
Structural highlights
FunctionM3K12_HUMAN May be an activator of the JNK/SAPK pathway. Phosphorylates beta-casein, histone 1 and myelin basic protein in vitro. See Also |
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