7l25: Difference between revisions
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==HPK1 IN COMPLEX WITH COMPOUND 18== | ==HPK1 IN COMPLEX WITH COMPOUND 18== | ||
<StructureSection load='7l25' size='340' side='right'caption='[[7l25]]' scene=''> | <StructureSection load='7l25' size='340' side='right'caption='[[7l25]], [[Resolution|resolution]] 1.85Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7L25 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7L25 FirstGlance]. <br> | <table><tr><td colspan='2'>[[7l25]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7L25 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7L25 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7l25 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7l25 OCA], [https://pdbe.org/7l25 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7l25 RCSB], [https://www.ebi.ac.uk/pdbsum/7l25 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7l25 ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=XHS:6-(2-fluoro-6-methoxyphenyl)-1-[6-(4-methylpiperazin-1-yl)pyridin-2-yl]-1H-pyrazolo[4,3-c]pyridine'>XHS</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7l25 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7l25 OCA], [https://pdbe.org/7l25 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7l25 RCSB], [https://www.ebi.ac.uk/pdbsum/7l25 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7l25 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/M4K1_HUMAN M4K1_HUMAN] Serine/threonine-protein kinase, which may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation. Able to autophosphorylate.<ref>PMID:24362026</ref> <ref>PMID:8824585</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Lesburg CA]] | [[Category: Lesburg CA]] | ||
Latest revision as of 10:18, 3 April 2024
HPK1 IN COMPLEX WITH COMPOUND 18HPK1 IN COMPLEX WITH COMPOUND 18
Structural highlights
FunctionM4K1_HUMAN Serine/threonine-protein kinase, which may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation. Able to autophosphorylate.[1] [2] References
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