6xg4: Difference between revisions

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-'''Unreleased structure'''
-The entry 6xg4 is ON HOLD
+==X-ray structure of Escherichia coli dihydrofolate reductase L28R mutant in complex with trimethoprim==
+<StructureSection load='6xg4' size='340' side='right'caption='[[6xg4]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6xg4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XG4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XG4 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=TOP:TRIMETHOPRIM'>TOP</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xg4 OCA], [https://pdbe.org/6xg4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xg4 RCSB], [https://www.ebi.ac.uk/pdbsum/6xg4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xg4 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/DYR_ECOLI DYR_ECOLI] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
-Authors: Gaszek, I.K., Manna, M.S., Borek, D., Toprak, E.
+==See Also==
+*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
-Description: X-ray structure of Escherichia coli dihydrofolate reductase L28R mutant in complex with trimethoprim
+__TOC__
-[[Category: Unreleased Structures]]
+</StructureSection>
-[[Category: Toprak, E]]
+[[Category: Escherichia coli K-12]]
-[[Category: Manna, M.S]]
+[[Category: Large Structures]]
-[[Category: Borek, D]]
+[[Category: Borek D]]
-[[Category: Gaszek, I.K]]
+[[Category: Gaszek IK]]
+[[Category: Manna MS]]
+[[Category: Toprak E]]