6xg4: Difference between revisions
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==X-ray structure of Escherichia coli dihydrofolate reductase L28R mutant in complex with trimethoprim== | |||
<StructureSection load='6xg4' size='340' side='right'caption='[[6xg4]], [[Resolution|resolution]] 2.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6xg4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XG4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XG4 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=TOP:TRIMETHOPRIM'>TOP</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xg4 OCA], [https://pdbe.org/6xg4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xg4 RCSB], [https://www.ebi.ac.uk/pdbsum/6xg4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xg4 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/DYR_ECOLI DYR_ECOLI] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | |||
==See Also== | |||
*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]] | |||
__TOC__ | |||
[[Category: | </StructureSection> | ||
[[Category: Borek | [[Category: Escherichia coli K-12]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Manna | [[Category: Borek D]] | ||
[[Category: | [[Category: Gaszek IK]] | ||
[[Category: Manna MS]] | |||
[[Category: Toprak E]] | |||
Latest revision as of 10:10, 3 April 2024
X-ray structure of Escherichia coli dihydrofolate reductase L28R mutant in complex with trimethoprimX-ray structure of Escherichia coli dihydrofolate reductase L28R mutant in complex with trimethoprim
Structural highlights
FunctionDYR_ECOLI Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. See Also |
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