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<StructureSection load='4yvm' size='340' side='right'caption='[[4yvm]], [[Resolution|resolution]] 2.79&Aring;' scene=''>
<StructureSection load='4yvm' size='340' side='right'caption='[[4yvm]], [[Resolution|resolution]] 2.79&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4yvm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43504 Atcc 43504]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YVM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YVM FirstGlance]. <br>
<table><tr><td colspan='2'>[[4yvm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YVM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YVM FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HP0539 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=210 ATCC 43504])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.791&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yvm OCA], [http://pdbe.org/4yvm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yvm RCSB], [http://www.ebi.ac.uk/pdbsum/4yvm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yvm ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yvm OCA], [https://pdbe.org/4yvm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yvm RCSB], [https://www.ebi.ac.uk/pdbsum/4yvm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yvm ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/Q75XL3_HELPX Q75XL3_HELPX]
Helicobacter pylori (Hp) CagL is a component of the type IV secretion system (T4SS) and interacts with integrin in host cells through its flexible RGD domain to translocate CagA. Differences in CagL amino acid polymorphisms between Western and East-Asian Hps are correlated with clinical outcome. CagL of East-Asian clinical Hp isolate K74 (CagL(K74)) contains multiple residue variations upstream of RGD motif and has different integrin binding affinities compared to those of CagL from Western Hp 26695. Here, we report the crystal structure of CagL(K74). The structure displayed a six-helix bundle including two short alpha-helices, and the RGD motif was found in the long rigid alpha2 helix flanked by the conserved protease-sensitive and RGD-helper sequences, as observed in CagL(26695). However, two additional salt bridges were found between the helices compared with the CagL(26695) structure, suggesting that the putative flexible region harboring the RGD motif may be more stable in this CagL variant.
 
Crystal structure of CagL from Helicobacter pylori K74 strain.,Choi JM, Choi YH, Sudhanva MS, Devakumar S, Lee KH, Cha JH, Lee SH Biochem Biophys Res Commun. 2015 May 15;460(4):964-70. doi:, 10.1016/j.bbrc.2015.03.135. Epub 2015 Apr 1. PMID:25839651<ref>PMID:25839651</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4yvm" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Atcc 43504]]
[[Category: Helicobacter pylori]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Cha, J H]]
[[Category: Cha JH]]
[[Category: Choi, J M]]
[[Category: Choi JM]]
[[Category: Choi, Y H]]
[[Category: Choi YH]]
[[Category: Lee, S H]]
[[Category: Lee SH]]
[[Category: Cagl]]
[[Category: Helicobacter pylori]]
[[Category: Protein binding]]
[[Category: Rgd domain]]
[[Category: T4ss]]

Latest revision as of 09:53, 3 April 2024

X-ray structure of Helicobacter pylori CagL-K74X-ray structure of Helicobacter pylori CagL-K74

Structural highlights

4yvm is a 2 chain structure with sequence from Helicobacter pylori. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.791Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q75XL3_HELPX

4yvm, resolution 2.79Å

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OCA
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