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[[Image:4ftb.png|left|200px]]


{{STRUCTURE_4ftb|  PDB=4ftb  |  SCENE=  }}
==Crystal structure of the authentic Flock House virus particle==
 
<StructureSection load='4ftb' size='340' side='right'caption='[[4ftb]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
===Crystal structure of the authentic Flock House virus particle===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4ftb]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Flock_House_virus Flock House virus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2z2q 2z2q]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FTB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FTB FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
==About this Structure==
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
[[4ftb]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Flock_house_virus Flock house virus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2z2q 2z2q]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FTB OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ftb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ftb OCA], [https://pdbe.org/4ftb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ftb RCSB], [https://www.ebi.ac.uk/pdbsum/4ftb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ftb ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CAPSD_FHV CAPSD_FHV] Capsid protein alpha self-assembles to form an icosahedral procapsid with a T=3 symmetry, about 30 nm in diameter, and consisting of 60 capsid proteins trimers. In addition, 240 calcium ions are incorporated per capsid during assembly. The capsid encapsulates the two genomic RNAs. Capsid maturation occurs via autoproteolytic cleavage of capsid protein alpha generating capsid protein beta and the membrane-active peptide gamma.  Peptide gamma: membrane-permeabilizing peptide produced by virus maturation, thereby creating the infectious virion. After endocytosis into the host cell, peptide gamma is probably exposed in endosomes, where it permeabilizes the endosomal membrane, facilitating translocation of viral capsid or RNA into the cytoplasm (Probable).


==See Also==
==See Also==
*[[Virus coat protein|Virus coat protein]]
*[[Flock house virus protein B2|Flock house virus protein B2]]
[[Category: Flock house virus]]
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
[[Category: Nodavirus endopeptidase]]
__TOC__
[[Category: Chen, Z.]]
</StructureSection>
[[Category: Johnson, J E.]]
[[Category: Flock House virus]]
[[Category: Reddy, V S.]]
[[Category: Large Structures]]
[[Category: Speir, J A.]]
[[Category: Chen Z]]
[[Category: Aspartyl protease]]
[[Category: Johnson JE]]
[[Category: Autoproteolysis]]
[[Category: Reddy VS]]
[[Category: Beta-barrel]]
[[Category: Speir JA]]
[[Category: Capsid protein]]
[[Category: Flock house virus]]
[[Category: Hydrolase]]
[[Category: Icosahedral virus]]
[[Category: Jellyroll]]
[[Category: Nodavirus]]
[[Category: Rna]]
[[Category: Virion]]
[[Category: Virus]]

Latest revision as of 09:47, 3 April 2024

Crystal structure of the authentic Flock House virus particleCrystal structure of the authentic Flock House virus particle

Structural highlights

4ftb is a 7 chain structure with sequence from Flock House virus. This structure supersedes the now removed PDB entry 2z2q. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.7Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CAPSD_FHV Capsid protein alpha self-assembles to form an icosahedral procapsid with a T=3 symmetry, about 30 nm in diameter, and consisting of 60 capsid proteins trimers. In addition, 240 calcium ions are incorporated per capsid during assembly. The capsid encapsulates the two genomic RNAs. Capsid maturation occurs via autoproteolytic cleavage of capsid protein alpha generating capsid protein beta and the membrane-active peptide gamma. Peptide gamma: membrane-permeabilizing peptide produced by virus maturation, thereby creating the infectious virion. After endocytosis into the host cell, peptide gamma is probably exposed in endosomes, where it permeabilizes the endosomal membrane, facilitating translocation of viral capsid or RNA into the cytoplasm (Probable).

See Also

4ftb, resolution 2.70Å

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