3knx: Difference between revisions

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[[Image:3knx.jpg|left|200px]]


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==HCV NS3 protease domain with P1-P3 macrocyclic ketoamide inhibitor==
The line below this paragraph, containing "STRUCTURE_3knx", creates the "Structure Box" on the page.
<StructureSection load='3knx' size='340' side='right'caption='[[3knx]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3knx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepatitis_C_virus_(isolate_H77) Hepatitis C virus (isolate H77)] and [https://en.wikipedia.org/wiki/Hepatitis_C_virus_genotype_1a Hepatitis C virus genotype 1a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KNX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KNX FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=JZT:(2R)-2-{(3S,13S,16AS,17AR,17BS)-13-[({(1S)-1-[(4,4-DIMETHYL-2,6-DIOXOPIPERIDIN-1-YL)METHYL]-2,2-DIMETHYLPROPYL}CARBAMOYL)AMINO]-17,17-DIMETHYL-1,14-DIOXOOCTADECAHYDRO-2H-CYCLOPROPA[3,4]PYRROLO[1,2-A][1,4]DIAZACYCLOHEXADECIN-3-YL}-2-HYDROXY-N-PROP-2-EN-1-YLETHANAMIDE'>JZT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_3knx|  PDB=3knx  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3knx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3knx OCA], [https://pdbe.org/3knx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3knx RCSB], [https://www.ebi.ac.uk/pdbsum/3knx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3knx ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q9ELS8_9HEPC Q9ELS8_9HEPC]


===HCV NS3 protease domain with P1-P3 macrocyclic ketoamide inhibitor===
==See Also==
 
*[[Virus protease 3D structures|Virus protease 3D structures]]
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_19102654}}, adds the Publication Abstract to the page
[[Category: Hepatitis C virus genotype 1a]]
(as it appears on PubMed at http://www.pubmed.gov), where 19102654 is the PubMed ID number.
[[Category: Large Structures]]
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[[Category: Agrawal S]]
{{ABSTRACT_PUBMED_19102654}}
[[Category: Blackman M]]
 
[[Category: Bogen S]]
==About this Structure==
[[Category: Chase R]]
3KNX is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Hepatitis_c_virus_subtype_1a Hepatitis c virus subtype 1a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KNX OCA].
[[Category: Chen KX]]
 
[[Category: Cheng K-C]]
==Reference==
[[Category: Girijavallabhan V]]
<ref group="xtra">PMID:19102654</ref><references group="xtra"/>
[[Category: Hart A]]
[[Category: Hepatitis c virus subtype 1a]]
[[Category: Nair L]]
[[Category: Agrawal, S.]]
[[Category: Njoroge FG]]
[[Category: Blackman, M.]]
[[Category: Pichardo J]]
[[Category: Bogen, S.]]
[[Category: Piwinski J]]
[[Category: Chase, R.]]
[[Category: Prongay A]]
[[Category: Chen, K X.]]
[[Category: Shih N-Y]]
[[Category: Cheng, K C.]]
[[Category: Tong X]]
[[Category: Girijavallabhan, V.]]
[[Category: Velazquez F]]
[[Category: Hart, A.]]
[[Category: Venkatraman S]]
[[Category: Nair, L.]]
[[Category: Wu W]]
[[Category: Njoroge, F G.]]
[[Category: Pichardo, J.]]
[[Category: Piwinski, J.]]
[[Category: Prongay, A.]]
[[Category: Shih, N Y.]]
[[Category: Tong, X.]]
[[Category: Velazquez, F.]]
[[Category: Venkatraman, S.]]
[[Category: Wu, W.]]
[[Category: Atp-binding]]
[[Category: Envelope protein]]
[[Category: Helicase]]
[[Category: Hepatitis c virus]]
[[Category: Hydrolase]]
[[Category: Macrocyclic ketoamide inhibitor]]
[[Category: Membrane]]
[[Category: Ns3 protease domain]]
[[Category: Nucleotide-binding]]
[[Category: Rna replication]]
[[Category: Serine protease]]
[[Category: Transmembrane]]
[[Category: Viral protein]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 27 12:09:19 2010''

Latest revision as of 09:40, 3 April 2024

HCV NS3 protease domain with P1-P3 macrocyclic ketoamide inhibitorHCV NS3 protease domain with P1-P3 macrocyclic ketoamide inhibitor

Structural highlights

3knx is a 4 chain structure with sequence from Hepatitis C virus (isolate H77) and Hepatitis C virus genotype 1a. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.65Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q9ELS8_9HEPC

See Also

3knx, resolution 2.65Å

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OCA
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