3knx: Difference between revisions
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New page: '''Unreleased structure''' The entry 3knx is ON HOLD Authors: Venkatraman, S.; Velazquez, F.; Wu, W.; Blackman, M.; Chen, K.X.; Bogen, S.; Nair, L.; Tong, X.; Chase, R.; Hart, A.; Agraw... |
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==HCV NS3 protease domain with P1-P3 macrocyclic ketoamide inhibitor== | |||
<StructureSection load='3knx' size='340' side='right'caption='[[3knx]], [[Resolution|resolution]] 2.65Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3knx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepatitis_C_virus_(isolate_H77) Hepatitis C virus (isolate H77)] and [https://en.wikipedia.org/wiki/Hepatitis_C_virus_genotype_1a Hepatitis C virus genotype 1a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KNX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KNX FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=JZT:(2R)-2-{(3S,13S,16AS,17AR,17BS)-13-[({(1S)-1-[(4,4-DIMETHYL-2,6-DIOXOPIPERIDIN-1-YL)METHYL]-2,2-DIMETHYLPROPYL}CARBAMOYL)AMINO]-17,17-DIMETHYL-1,14-DIOXOOCTADECAHYDRO-2H-CYCLOPROPA[3,4]PYRROLO[1,2-A][1,4]DIAZACYCLOHEXADECIN-3-YL}-2-HYDROXY-N-PROP-2-EN-1-YLETHANAMIDE'>JZT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3knx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3knx OCA], [https://pdbe.org/3knx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3knx RCSB], [https://www.ebi.ac.uk/pdbsum/3knx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3knx ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/Q9ELS8_9HEPC Q9ELS8_9HEPC] | |||
==See Also== | |||
*[[Virus protease 3D structures|Virus protease 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Hepatitis C virus genotype 1a]] | |||
[[Category: Large Structures]] | |||
[[Category: Agrawal S]] | |||
[[Category: Blackman M]] | |||
[[Category: Bogen S]] | |||
[[Category: Chase R]] | |||
[[Category: Chen KX]] | |||
[[Category: Cheng K-C]] | |||
[[Category: Girijavallabhan V]] | |||
[[Category: Hart A]] | |||
[[Category: Nair L]] | |||
[[Category: Njoroge FG]] | |||
[[Category: Pichardo J]] | |||
[[Category: Piwinski J]] | |||
[[Category: Prongay A]] | |||
[[Category: Shih N-Y]] | |||
[[Category: Tong X]] | |||
[[Category: Velazquez F]] | |||
[[Category: Venkatraman S]] | |||
[[Category: Wu W]] | |||
Latest revision as of 09:40, 3 April 2024
HCV NS3 protease domain with P1-P3 macrocyclic ketoamide inhibitorHCV NS3 protease domain with P1-P3 macrocyclic ketoamide inhibitor
Structural highlights
FunctionSee Also |
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