2o1u: Difference between revisions

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[[Image:2o1u.png|left|200px]]


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==Structure of full length GRP94 with AMP-PNP bound==
The line below this paragraph, containing "STRUCTURE_2o1u", creates the "Structure Box" on the page.
<StructureSection load='2o1u' size='340' side='right'caption='[[2o1u]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2o1u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. The December 2008 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Hsp90''  by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2008_12 10.2210/rcsb_pdb/mom_2008_12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O1U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O1U FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
{{STRUCTURE_2o1u|  PDB=2o1u  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o1u OCA], [https://pdbe.org/2o1u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o1u RCSB], [https://www.ebi.ac.uk/pdbsum/2o1u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o1u ProSAT]</span></td></tr>
 
</table>
===Structure of full length GRP94 with AMP-PNP bound===
== Function ==
 
[https://www.uniprot.org/uniprot/ENPL_CANLF ENPL_CANLF] Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity (By similarity).
 
== Evolutionary Conservation ==
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    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
[[2o1u]] is a 2 chain structure of [[Endoplasmin]] and [[Heat Shock Proteins]] with sequence from [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. The December 2008 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Hsp90''  by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2008_12 10.2210/rcsb_pdb/mom_2008_12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O1U OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2o1u ConSurf].
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==See Also==
==See Also==
*[[Endoplasmin]]
*[[Heat Shock Protein structures|Heat Shock Protein structures]]
*[[Heat Shock Proteins]]
__TOC__
 
</StructureSection>
==Reference==
<ref group="xtra">PMID:17936703</ref><references group="xtra"/>
[[Category: Canis lupus familiaris]]
[[Category: Canis lupus familiaris]]
[[Category: Hsp90]]
[[Category: Hsp90]]
[[Category: Large Structures]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: Dollins, D E.]]
[[Category: Dollins DE]]
[[Category: Gewirth, D T.]]
[[Category: Gewirth DT]]
[[Category: Immormino, R M.]]
[[Category: Immormino RM]]
[[Category: Warren, J J.]]
[[Category: Warren JJ]]
[[Category: Amp-pnp]]
[[Category: Chaperone]]
[[Category: Endoplasmin]]
[[Category: Gp96]]
[[Category: Grp94]]
[[Category: Hsp82]]
[[Category: Hsp90]]
[[Category: Htpg]]

Latest revision as of 09:28, 3 April 2024

Structure of full length GRP94 with AMP-PNP boundStructure of full length GRP94 with AMP-PNP bound

Structural highlights

2o1u is a 2 chain structure with sequence from Canis lupus familiaris. The December 2008 RCSB PDB Molecule of the Month feature on Hsp90 by David Goodsell is 10.2210/rcsb_pdb/mom_2008_12. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.4Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ENPL_CANLF Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2o1u, resolution 2.40Å

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OCA
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