2nrc: Difference between revisions

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{{Seed}}
[[Image:2nrc.png|left|200px]]


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==C28A Mutant of Succinyl-CoA:3-Ketoacid CoA Transferase from Pig Heart==
The line below this paragraph, containing "STRUCTURE_2nrc", creates the "Structure Box" on the page.
<StructureSection load='2nrc' size='340' side='right'caption='[[2nrc]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2nrc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NRC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NRC FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nrc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nrc OCA], [https://pdbe.org/2nrc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nrc RCSB], [https://www.ebi.ac.uk/pdbsum/2nrc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nrc ProSAT]</span></td></tr>
{{STRUCTURE_2nrc|  PDB=2nrc  |  SCENE=  }}
</table>
 
== Function ==
===C28A Mutant of Succinyl-CoA:3-Ketoacid CoA Transferase from Pig Heart===
[https://www.uniprot.org/uniprot/SCOT1_PIG SCOT1_PIG] Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
The line below this paragraph, {{ABSTRACT_PUBMED_17718512}}, adds the Publication Abstract to the page
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nr/2nrc_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_17718512}}
    <text>to colour the structure by Evolutionary Conservation</text>
 
  </jmolCheckbox>
==About this Structure==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2nrc ConSurf].
2NRC is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NRC OCA].  
<div style="clear:both"></div>
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:17718512</ref><references group="xtra"/>
[[Category: Large Structures]]
[[Category: 3-oxoacid CoA-transferase]]
[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
[[Category: Fraser, M E.]]
[[Category: Fraser ME]]
[[Category: Tammam, S D.]]
[[Category: Tammam SD]]
[[Category: Alpha/beta protein]]
[[Category: Transferase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 11:30:24 2009''

Latest revision as of 09:28, 3 April 2024

C28A Mutant of Succinyl-CoA:3-Ketoacid CoA Transferase from Pig HeartC28A Mutant of Succinyl-CoA:3-Ketoacid CoA Transferase from Pig Heart

Structural highlights

2nrc is a 4 chain structure with sequence from Sus scrofa. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.05Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SCOT1_PIG Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

2nrc, resolution 2.05Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
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