1z4u: Difference between revisions

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-[[Image:1z4u.gif|left|200px]]
-<!--
+==hepatitis C virus NS5B RNA-dependent RNA polymerase complex with inhibitor PHA-00799585==
-The line below this paragraph, containing "STRUCTURE_1z4u", creates the "Structure Box" on the page.
+<StructureSection load='1z4u' size='340' side='right'caption='[[1z4u]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1z4u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepacivirus_C Hepacivirus C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z4U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z4U FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PH9:(2Z)-2-[(1-ADAMANTYLCARBONYL)AMINO]-3-[4-(2-BROMOPHENOXY)PHENYL]PROP-2-ENOIC+ACID'>PH9</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-{{STRUCTURE_1z4u|  PDB=1z4u  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z4u OCA], [https://pdbe.org/1z4u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z4u RCSB], [https://www.ebi.ac.uk/pdbsum/1z4u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z4u ProSAT]</span></td></tr>
+</table>
-'''hepatitis C virus NS5B RNA-dependent RNA polymerase complex with inhibitor PHA-00799585'''
+== Function ==
+[https://www.uniprot.org/uniprot/O93077_9HEPC O93077_9HEPC]
+== Evolutionary Conservation ==
-==Overview==
+[[Image:Consurf_key_small.gif|200px|right]]
-A novel series of non-nucleoside HCV NS5B polymerase inhibitors was prepared from a (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid template. Solution and solid phase analog synthesis focused on the northern region of the template combined with structure based design led to the discovery of several potent and orally bioavailable lead compounds.
+Check<jmol>
+  <jmolCheckbox>
-==About this Structure==
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z4/1z4u_consurf.spt"</scriptWhenChecked>
-Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z4U OCA].
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
-==Reference==
+  </jmolCheckbox>
-Inhibitors of HCV NS5B polymerase. Part 2: Evaluation of the northern region of (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid., Pfefferkorn JA, Nugent R, Gross RJ, Greene M, Mitchell MA, Reding MT, Funk LA, Anderson R, Wells PA, Shelly JA, Anstadt R, Finzel BC, Harris MS, Kilkuskie RE, Kopta LA, Schwende FJ, Bioorg Med Chem Lett. 2005 Jun 2;15(11):2812-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15911260 15911260]
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z4u ConSurf].
-[[Category: RNA-directed RNA polymerase]]
+<div style="clear:both"></div>
-[[Category: Anstadt, R.]]
+__TOC__
-[[Category: Finzel, B C.]]
+</StructureSection>
-[[Category: Greene, M.]]
+[[Category: Hepacivirus C]]
-[[Category: Gross, R J.]]
+[[Category: Large Structures]]
-[[Category: Harris, M S.]]
+[[Category: Anstadt R]]
-[[Category: Mitchell, M A.]]
+[[Category: Finzel BC]]
-[[Category: Nugent, R.]]
+[[Category: Greene M]]
-[[Category: Pfefferkorn, J A.]]
+[[Category: Gross RJ]]
-[[Category: Shelly, J A.]]
+[[Category: Harris MS]]
-[[Category: Wells, P A.]]
+[[Category: Mitchell MA]]
-[[Category: Finger]]
+[[Category: Nugent R]]
-[[Category: Hcv]]
+[[Category: Pfefferkorn JA]]
-[[Category: Ns5b]]
+[[Category: Shelly JA]]
-[[Category: Palm]]
+[[Category: Wells PA]]
-[[Category: Polymerase]]
-[[Category: Thumb]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 17:10:43 2008''