1z4u: Difference between revisions

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 ==hepatitis C virus NS5B RNA-dependent RNA polymerase complex with inhibitor PHA-00799585==
-<StructureSection load='1z4u' size='340' side='right' caption='[[1z4u]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
+<StructureSection load='1z4u' size='340' side='right'caption='[[1z4u]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1z4u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z4U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z4U FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1z4u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepacivirus_C Hepacivirus C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z4U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z4U FirstGlance]. <br>
-</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PH9:(2Z)-2-[(1-ADAMANTYLCARBONYL)AMINO]-3-[4-(2-BROMOPHENOXY)PHENYL]PROP-2-ENOIC+ACID'>PH9</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
-<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1yvf|1yvf]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PH9:(2Z)-2-[(1-ADAMANTYLCARBONYL)AMINO]-3-[4-(2-BROMOPHENOXY)PHENYL]PROP-2-ENOIC+ACID'>PH9</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z4u OCA], [https://pdbe.org/1z4u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z4u RCSB], [https://www.ebi.ac.uk/pdbsum/1z4u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z4u ProSAT]</span></td></tr>
-<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z4u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1z4u RCSB], [http://www.ebi.ac.uk/pdbsum/1z4u PDBsum]</span></td></tr>
+</table>
-<table>
+== Function ==
+[https://www.uniprot.org/uniprot/O93077_9HEPC O93077_9HEPC]
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
 Check<jmol>
    <jmolCheckbox>
-     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z4/1z4u_consurf.spt"</scriptWhenChecked>
+     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z4/1z4u_consurf.spt"</scriptWhenChecked>
      <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
      <text>to colour the structure by Evolutionary Conservation</text>
    </jmolCheckbox>
-</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z4u ConSurf].
 <div style="clear:both"></div>
-<div style="background-color:#fffaf0;">
-== Publication Abstract from PubMed ==
-A novel series of non-nucleoside HCV NS5B polymerase inhibitors was prepared from a (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid template. Solution and solid phase analog synthesis focused on the northern region of the template combined with structure based design led to the discovery of several potent and orally bioavailable lead compounds.
-Inhibitors of HCV NS5B polymerase. Part 2: Evaluation of the northern region of (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid.,Pfefferkorn JA, Nugent R, Gross RJ, Greene M, Mitchell MA, Reding MT, Funk LA, Anderson R, Wells PA, Shelly JA, Anstadt R, Finzel BC, Harris MS, Kilkuskie RE, Kopta LA, Schwende FJ Bioorg Med Chem Lett. 2005 Jun 2;15(11):2812-8. PMID:15911260<ref>PMID:15911260</ref>
-From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-</div>
-== References ==
-<references/>
 __TOC__
 </StructureSection>
-[[Category: Hepatitis c virus]]
+[[Category: Hepacivirus C]]
-[[Category: RNA-directed RNA polymerase]]
+[[Category: Large Structures]]
-[[Category: Anstadt, R.]]
+[[Category: Anstadt R]]
-[[Category: Finzel, B C.]]
+[[Category: Finzel BC]]
-[[Category: Greene, M.]]
+[[Category: Greene M]]
-[[Category: Gross, R J.]]
+[[Category: Gross RJ]]
-[[Category: Harris, M S.]]
+[[Category: Harris MS]]
-[[Category: Mitchell, M A.]]
+[[Category: Mitchell MA]]
-[[Category: Nugent, R.]]
+[[Category: Nugent R]]
-[[Category: Pfefferkorn, J A.]]
+[[Category: Pfefferkorn JA]]
-[[Category: Shelly, J A.]]
+[[Category: Shelly JA]]
-[[Category: Wells, P A.]]
+[[Category: Wells PA]]
-[[Category: Finger]]
-[[Category: Hcv]]
-[[Category: Ns5b]]
-[[Category: Palm]]
-[[Category: Polymerase]]
-[[Category: Thumb]]
-[[Category: Transferase]]