1z4u: Difference between revisions

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OCA

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-[[Image:1z4u.png|left|200px]]
-{{STRUCTURE_1z4u|  PDB=1z4u  |  SCENE=  }}
+==hepatitis C virus NS5B RNA-dependent RNA polymerase complex with inhibitor PHA-00799585==
+<StructureSection load='1z4u' size='340' side='right'caption='[[1z4u]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
-===hepatitis C virus NS5B RNA-dependent RNA polymerase complex with inhibitor PHA-00799585===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1z4u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepacivirus_C Hepacivirus C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z4U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z4U FirstGlance]. <br>
-{{ABSTRACT_PUBMED_15911260}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PH9:(2Z)-2-[(1-ADAMANTYLCARBONYL)AMINO]-3-[4-(2-BROMOPHENOXY)PHENYL]PROP-2-ENOIC+ACID'>PH9</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z4u OCA], [https://pdbe.org/1z4u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z4u RCSB], [https://www.ebi.ac.uk/pdbsum/1z4u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z4u ProSAT]</span></td></tr>
-[[1z4u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z4U OCA].
+</table>
+== Function ==
-==Reference==
+[https://www.uniprot.org/uniprot/O93077_9HEPC O93077_9HEPC]
-<ref group="xtra">PMID:015911260</ref><references group="xtra"/>
+== Evolutionary Conservation ==
-[[Category: Hepatitis c virus]]
+[[Image:Consurf_key_small.gif|200px|right]]
-[[Category: RNA-directed RNA polymerase]]
+Check<jmol>
-[[Category: Anstadt, R.]]
+  <jmolCheckbox>
-[[Category: Finzel, B C.]]
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z4/1z4u_consurf.spt"</scriptWhenChecked>
-[[Category: Greene, M.]]
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-[[Category: Gross, R J.]]
+    <text>to colour the structure by Evolutionary Conservation</text>
-[[Category: Harris, M S.]]
+  </jmolCheckbox>
-[[Category: Mitchell, M A.]]
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z4u ConSurf].
-[[Category: Nugent, R.]]
+<div style="clear:both"></div>
-[[Category: Pfefferkorn, J A.]]
+__TOC__
-[[Category: Shelly, J A.]]
+</StructureSection>
-[[Category: Wells, P A.]]
+[[Category: Hepacivirus C]]
-[[Category: Finger]]
+[[Category: Large Structures]]
-[[Category: Hcv]]
+[[Category: Anstadt R]]
-[[Category: Ns5b]]
+[[Category: Finzel BC]]
-[[Category: Palm]]
+[[Category: Greene M]]
-[[Category: Polymerase]]
+[[Category: Gross RJ]]
-[[Category: Thumb]]
+[[Category: Harris MS]]
-[[Category: Transferase]]
+[[Category: Mitchell MA]]
+[[Category: Nugent R]]
+[[Category: Pfefferkorn JA]]
+[[Category: Shelly JA]]
+[[Category: Wells PA]]