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==CGL2 ligandfree==
==CGL2 ligandfree==
<StructureSection load='1ul9' size='340' side='right' caption='[[1ul9]], [[Resolution|resolution]] 2.22&Aring;' scene=''>
<StructureSection load='1ul9' size='340' side='right'caption='[[1ul9]], [[Resolution|resolution]] 2.22&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1ul9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Copci Copci]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UL9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UL9 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1ul9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Coprinopsis_cinerea Coprinopsis cinerea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UL9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UL9 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1sla|1sla]], [[1qmj|1qmj]], [[1gan|1gan]], [[1c1f|1c1f]], [[1bkz|1bkz]], [[1a3k|1a3k]], [[1lcl|1lcl]], [[1is5|1is5]], [[1ulc|1ulc]], [[1uld|1uld]], [[1ule|1ule]], [[1ulf|1ulf]], [[1ulg|1ulg]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.22&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cgl2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5346 COPCI])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ul9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ul9 OCA], [https://pdbe.org/1ul9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ul9 RCSB], [https://www.ebi.ac.uk/pdbsum/1ul9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ul9 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ul9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ul9 OCA], [http://pdbe.org/1ul9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ul9 RCSB], [http://www.ebi.ac.uk/pdbsum/1ul9 PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CGL2_COPCI CGL2_COPCI]] Binds lactose. May play a role in fruiting body formation.<ref>PMID:8999822</ref>
[https://www.uniprot.org/uniprot/CGL2_COPCI CGL2_COPCI] Binds lactose. May play a role in fruiting body formation.<ref>PMID:8999822</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ul/1ul9_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ul/1ul9_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
Line 19: Line 19:
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ul9 ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ul9 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Recognition of and discrimination between potential glyco-substrates is central to the function of galectins. Here we dissect the fundamental parameters responsible for such selectivity by the fungal representative, CGL2. The 2.1 A crystal structure of CGL2 and five substrate complexes reveal that this prototype galectin achieves increased substrate specificity by accommodating substituted oligosaccharides of the mammalian blood group A/B type in an extended binding cleft. Kinetic studies on wild-type and mutant CGL2 proteins demonstrate that the tetrameric organization is essential for functionality. The geometric constraints due to the orthogonal orientation of the four binding sites have important consequences on substrate binding and selectivity.
Structure and functional analysis of the fungal galectin CGL2.,Walser PJ, Haebel PW, Kunzler M, Sargent D, Kues U, Aebi M, Ban N Structure. 2004 Apr;12(4):689-702. PMID:15062091<ref>PMID:15062091</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1ul9" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Galectin|Galectin]]
*[[Galectin 3D structures|Galectin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Copci]]
[[Category: Coprinopsis cinerea]]
[[Category: Aebi, M]]
[[Category: Large Structures]]
[[Category: Ban, N]]
[[Category: Aebi M]]
[[Category: Haebel, P W]]
[[Category: Ban N]]
[[Category: Kuenzler, M]]
[[Category: Haebel PW]]
[[Category: Kues, U]]
[[Category: Kuenzler M]]
[[Category: Walser, P J]]
[[Category: Kues U]]
[[Category: Beta-galactoside binding lectin]]
[[Category: Walser PJ]]
[[Category: Galectin]]
[[Category: Lectin]]
[[Category: Sugar binding]]
[[Category: Sugar binding protein]]

Latest revision as of 09:16, 3 April 2024

CGL2 ligandfreeCGL2 ligandfree

Structural highlights

1ul9 is a 2 chain structure with sequence from Coprinopsis cinerea. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.22Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CGL2_COPCI Binds lactose. May play a role in fruiting body formation.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Cooper DN, Boulianne RP, Charlton S, Farrell EM, Sucher A, Lu BC. Fungal galectins, sequence and specificity of two isolectins from Coprinus cinereus. J Biol Chem. 1997 Jan 17;272(3):1514-21. PMID:8999822

1ul9, resolution 2.22Å

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