1m24: Difference between revisions

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-[[Image:1m24.jpg|left|200px]]<br /><applet load="1m24" size="350" color="white" frame="true" align="right" spinBox="true"
-caption="1m24, resolution 0.90&Aring;" />
-'''Trichotoxin_A50E, An Ion Channel-Forming Polypeptide'''<br />
-==Overview==
+==Trichotoxin_A50E, An Ion Channel-Forming Polypeptide==
-Trichotoxin_A50E is an 18-residue peptaibol antibiotic which forms multimeric transmembrane channels through self-association. The crystal structure of trichotoxin has been determined at a resolution of 0.9 A. The trichotoxin sequence contains nine helix-promoting Aib residues, which contribute to the formation of an entirely helical structure that has a central bend of 8-10 degrees located between residues 10-13. Trichotoxin is the first solved structure of the peptaibol family that is all alpha-helix as opposed to containing part or all 3(10)-helix. Gln residues in positions 6 and 17 produce a polar face, and are proposed to form the channel lumen. An octameric model channel has been constructed from the crystal structure. It has a central pore of approximately 4-5 A radius, a size sufficient to enable transport of ions, with a constricted region at one end, formed by a ring of Gln6 residues. Electrostatic calculations are consistent with it being a cationic channel.
+<StructureSection load='1m24' size='340' side='right'caption='[[1m24]], [[Resolution|resolution]] 0.90&Aring;' scene=''>
+== Structural highlights ==
-==About this Structure==
+<table><tr><td colspan='2'>[[1m24]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trichoderma_viride Trichoderma viride]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M24 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M24 FirstGlance]. <br>
-M24 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Trichoderma_viride Trichoderma viride] with <scene name='pdbligand=ACE:'>ACE</scene> and <scene name='pdbligand=CCN:'>CCN</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M24 OCA].
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.9&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=AIB:ALPHA-AMINOISOBUTYRIC+ACID'>AIB</scene>, <scene name='pdbligand=CCN:ACETONITRILE'>CCN</scene>, <scene name='pdbligand=PRD_000160:TRICHOTOXIN+A50E'>PRD_000160</scene>, <scene name='pdbligand=VOL:L-VALINOL'>VOL</scene></td></tr>
-==Reference==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m24 OCA], [https://pdbe.org/1m24 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m24 RCSB], [https://www.ebi.ac.uk/pdbsum/1m24 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m24 ProSAT]</span></td></tr>
-Model for a helical bundle channel based on the high-resolution crystal structure of trichotoxin_A50E., Chugh JK, Bruckner H, Wallace BA, Biochemistry. 2002 Oct 29;41(43):12934-41. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12390019 12390019]
+</table>
-[[Category: Protein complex]]
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Trichoderma viride]]
-[[Category: Brueckner, H.]]
+[[Category: Brueckner H]]
-[[Category: Chugh, J K.]]
+[[Category: Chugh JK]]
-[[Category: Wallace, B A.]]
+[[Category: Wallace BA]]
-[[Category: ACE]]
-[[Category: CCN]]
-[[Category: antibiotic]]
-[[Category: helical bundle]]
-[[Category: ion channel]]
-[[Category: peptaibol]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:50:41 2008''