1ksj: Difference between revisions

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-[[Image:1ksj.png|left|200px]]
-{{STRUCTURE_1ksj|  PDB=1ksj  |  SCENE=  }}
+==Complex of Arl2 and PDE delta, Crystal Form 2 (SeMet)==
+<StructureSection load='1ksj' size='340' side='right'caption='[[1ksj]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
-===Complex of Arl2 and PDE delta, Crystal Form 2 (SeMet)===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1ksj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KSJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KSJ FirstGlance]. <br>
-{{ABSTRACT_PUBMED_11980706}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ksj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ksj OCA], [https://pdbe.org/1ksj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ksj RCSB], [https://www.ebi.ac.uk/pdbsum/1ksj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ksj ProSAT]</span></td></tr>
-[[1ksj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KSJ OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ARL2_MOUSE ARL2_MOUSE] Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ks/1ksj_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ksj ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Phosphodiesterase|Phosphodiesterase]]
+*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
+__TOC__
-==Reference==
+</StructureSection>
-<ref group="xtra">PMID:011980706</ref><references group="xtra"/>
-[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]]
 [[Category: Homo sapiens]]
+[[Category: Large Structures]]
 [[Category: Mus musculus]]
-[[Category: Hanzal-Bayer, M.]]
+[[Category: Hanzal-Bayer M]]
-[[Category: Hillig, R C.]]
+[[Category: Hillig RC]]
-[[Category: Renault, L.]]
+[[Category: Renault L]]
-[[Category: Roversi, P.]]
+[[Category: Roversi P]]
-[[Category: Wittinghofer, A.]]
+[[Category: Wittinghofer A]]
-[[Category: Arf family]]
-[[Category: Effector molecule]]
-[[Category: Gdi]]
-[[Category: Immunoglobuline-like fold]]
-[[Category: Signaling protein-hydrolase complex]]
-[[Category: Small gtp-binding protein]]
-[[Category: Small gtpase]]