1b3k: Difference between revisions

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-[[Image:1b3k.png|left|200px]]
-{{STRUCTURE_1b3k|  PDB=1b3k  |  SCENE=  }}
+==Plasminogen activator inhibitor-1==
+<StructureSection load='1b3k' size='340' side='right'caption='[[1b3k]], [[Resolution|resolution]] 2.99&Aring;' scene=''>
-===Plasminogen activator inhibitor-1===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1b3k]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B3K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B3K FirstGlance]. <br>
-{{ABSTRACT_PUBMED_10368279}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.99&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b3k OCA], [https://pdbe.org/1b3k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b3k RCSB], [https://www.ebi.ac.uk/pdbsum/1b3k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b3k ProSAT]</span></td></tr>
-==About this Structure==
+</table>
-[[1b3k]] is a 4 chain structure of [[Plasminogen activator inhibitor]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B3K OCA].
+== Disease ==
+[https://www.uniprot.org/uniprot/PAI1_HUMAN PAI1_HUMAN] Defects in SERPINE1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1D) [MIM:[https://omim.org/entry/613329 613329]. It is a hematologic disorder characterized by increased bleeding after trauma, injury, or surgery. Affected females have menorrhagia. The bleeding defect is due to increased fibrinolysis of fibrin blood clots due to deficiency of plasminogen activator inhibitor-1, which inhibits tissue and urinary activators of plasminogen.<ref>PMID:9207454</ref>   Note=High concentrations of SERPINE1 seem to contribute to the development of venous but not arterial occlusions.
+== Function ==
+[https://www.uniprot.org/uniprot/PAI1_HUMAN PAI1_HUMAN] Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis.<ref>PMID:15853774</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b3/1b3k_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1b3k ConSurf].
+<div style="clear:both"></div>
 ==See Also==
 *[[Plasminogen activator inhibitor|Plasminogen activator inhibitor]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:010368279</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Pannu, N S.]]
+[[Category: Large Structures]]
-[[Category: Read, R J.]]
+[[Category: Pannu NS]]
-[[Category: Sharp, A M.]]
+[[Category: Read RJ]]
-[[Category: Stein, P E.]]
+[[Category: Sharp AM]]
-[[Category: Blood clotting]]
+[[Category: Stein PE]]
-[[Category: Inhibitor]]
-[[Category: Pai-1]]
-[[Category: Serpin]]