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[[Image:1av2.gif|left|200px]]<br /><applet load="1av2" size="350" color="white" frame="true" align="right" spinBox="true"
caption="1av2, resolution 1.4&Aring;" />
'''GRAMICIDIN A/CSCL COMPLEX, ACTIVE AS A DIMER'''<br />


==Overview==
==Gramicidin A/CsCl complex, active as a dimer==
The linear pentadecapeptide antibiotic, gramicidin D, is a naturally occurring product of Bacillus brevis known to form ion channels in synthetic and natural membranes. The x-ray crystal structures of the right-handed double-stranded double-helical dimers (DSDH) reported here agree with 15N-NMR and CD data on the functional gramicidin D channel in lipid bilayers. These structures demonstrate single-file ion transfer through the channels. The results also indicate that previous crystal structure reports of a left-handed double-stranded double-helical dimer in complex with Cs+ and K+ salts may be in error and that our evidence points to the DSDH as the major conformer responsible for ion transport in membranes.
<StructureSection load='1av2' size='340' side='right'caption='[[1av2]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1av2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Brevibacillus_brevis Brevibacillus brevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AV2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AV2 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CS:CESIUM+ION'>CS</scene>, <scene name='pdbligand=DLE:D-LEUCINE'>DLE</scene>, <scene name='pdbligand=DVA:D-VALINE'>DVA</scene>, <scene name='pdbligand=ETA:ETHANOLAMINE'>ETA</scene>, <scene name='pdbligand=FVA:N-FORMYL-L-VALINE'>FVA</scene>, <scene name='pdbligand=MOH:METHANOL'>MOH</scene>, <scene name='pdbligand=PRD_000150:GRAMICIDIN+A'>PRD_000150</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1av2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1av2 OCA], [https://pdbe.org/1av2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1av2 RCSB], [https://www.ebi.ac.uk/pdbsum/1av2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1av2 ProSAT]</span></td></tr>
</table>


==About this Structure==
==See Also==
1AV2 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Brevibacillus_brevis Brevibacillus brevis] with <scene name='pdbligand=CS:'>CS</scene>, <scene name='pdbligand=CL:'>CL</scene>, <scene name='pdbligand=FOR:'>FOR</scene> and <scene name='pdbligand=MOH:'>MOH</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AV2 OCA].
*[[Gramicidin|Gramicidin]]
 
__TOC__
==Reference==
</StructureSection>
The conducting form of gramicidin A is a right-handed double-stranded double helix., Burkhart BM, Li N, Langs DA, Pangborn WA, Duax WL, Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):12950-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9789021 9789021]
[[Category: Brevibacillus brevis]]
[[Category: Brevibacillus brevis]]
[[Category: Protein complex]]
[[Category: Large Structures]]
[[Category: Burkhart, B M.]]
[[Category: Burkhart BM]]
[[Category: Duax, W L.]]
[[Category: Duax WL]]
[[Category: Langs, D A.]]
[[Category: Langs DA]]
[[Category: Li, N.]]
[[Category: Li N]]
[[Category: CL]]
[[Category: CS]]
[[Category: FOR]]
[[Category: MOH]]
[[Category: ion channel]]
[[Category: peptide antibiotic]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:48:33 2008''

Latest revision as of 08:55, 3 April 2024

Gramicidin A/CsCl complex, active as a dimerGramicidin A/CsCl complex, active as a dimer

Structural highlights

1av2 is a 4 chain structure with sequence from Brevibacillus brevis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.4Å
Ligands:, , , , , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

See Also

1av2, resolution 1.40Å

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