8qud: Difference between revisions

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'''Unreleased structure'''


The entry 8qud is ON HOLD  until Paper Publication
==Cryo-EM Structure of Human Kv3.1 in Complex with Modulator AUT5==
 
<StructureSection load='8qud' size='340' side='right'caption='[[8qud]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8qud]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8QUD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8QUD FirstGlance]. <br>
Description:  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PCF:1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE'>PCF</scene>, <scene name='pdbligand=WY0:(5R)-5-ethyl-3-(6-spiro[2H-1-benzofuran-3,1-cyclopropane]-4-yloxypyridin-3-yl)imidazolidine-2,4-dione'>WY0</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8qud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8qud OCA], [https://pdbe.org/8qud PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8qud RCSB], [https://www.ebi.ac.uk/pdbsum/8qud PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8qud ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/KCNC1_HUMAN KCNC1_HUMAN] Progressive myoclonic epilepsy type 7. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/KCNC1_HUMAN KCNC1_HUMAN] Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient (PubMed:25401298). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well. Contributes to fire sustained trains of very brief action potentials at high frequency in pallidal neurons.[UniProtKB:P25122]<ref>PMID:25401298</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Alvaro GS]]
[[Category: Bakshi S]]
[[Category: Brooke LM]]
[[Category: Chi G]]
[[Category: Gunthorpe M]]
[[Category: Lakshminarayana B]]
[[Category: Large CH]]
[[Category: Marasco A]]
[[Category: Marsden B]]
[[Category: Mckinley G]]
[[Category: Pike ACW]]
[[Category: Pilati N]]
[[Category: Sauer DB]]
[[Category: Williams E]]
[[Category: Ye M]]

Latest revision as of 08:49, 3 April 2024

Cryo-EM Structure of Human Kv3.1 in Complex with Modulator AUT5Cryo-EM Structure of Human Kv3.1 in Complex with Modulator AUT5

Structural highlights

8qud is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Electron Microscopy, Resolution 2.5Å
Ligands:, , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

KCNC1_HUMAN Progressive myoclonic epilepsy type 7. The disease is caused by variants affecting the gene represented in this entry.

Function

KCNC1_HUMAN Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient (PubMed:25401298). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well. Contributes to fire sustained trains of very brief action potentials at high frequency in pallidal neurons.[UniProtKB:P25122][1]

References

  1. ↑ Muona M, Berkovic SF, Dibbens LM, Oliver KL, Maljevic S, Bayly MA, Joensuu T, Canafoglia L, Franceschetti S, Michelucci R, Markkinen S, Heron SE, Hildebrand MS, Andermann E, Andermann F, Gambardella A, Tinuper P, Licchetta L, Scheffer IE, Criscuolo C, Filla A, Ferlazzo E, Ahmad J, Ahmad A, Baykan B, Said E, Topcu M, Riguzzi P, King MD, Ozkara C, Andrade DM, Engelsen BA, Crespel A, Lindenau M, Lohmann E, Saletti V, Massano J, Privitera M, Espay AJ, Kauffmann B, Duchowny M, Møller RS, Straussberg R, Afawi Z, Ben-Zeev B, Samocha KE, Daly MJ, Petrou S, Lerche H, Palotie A, Lehesjoki AE. A recurrent de novo mutation in KCNC1 causes progressive myoclonus epilepsy. Nat Genet. 2015 Jan;47(1):39-46. PMID:25401298 doi:10.1038/ng.3144

8qud, resolution 2.50Å

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