1hsq: Difference between revisions

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-[[Image:1hsq.png|left|200px]]
-{{STRUCTURE_1hsq|  PDB=1hsq  |  SCENE=  }}
+==SOLUTION STRUCTURE OF THE SH3 DOMAIN OF PHOSPHOLIPASE CGAMMA==
+<StructureSection load='1hsq' size='340' side='right'caption='[[1hsq]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1hsq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HSQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HSQ FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hsq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hsq OCA], [https://pdbe.org/1hsq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hsq RCSB], [https://www.ebi.ac.uk/pdbsum/1hsq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hsq ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PLCG1_HUMAN PLCG1_HUMAN] Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration.<ref>PMID:17229814</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hs/1hsq_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hsq ConSurf].
+<div style="clear:both"></div>
-===SOLUTION STRUCTURE OF THE SH3 DOMAIN OF PHOSPHOLIPASE CGAMMA===
+==See Also==
+*[[Phospholipase C|Phospholipase C]]
-{{ABSTRACT_PUBMED_7681365}}
+== References ==
+<references/>
-==About this Structure==
+__TOC__
-[[1hsq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HSQ OCA].
+</StructureSection>
-==Reference==
-<ref group="xtra">PMID:007681365</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Phosphoinositide phospholipase C]]
+[[Category: Large Structures]]
-[[Category: Hatanaka, H.]]
+[[Category: Hatanaka H]]
-[[Category: Inagaki, F.]]
+[[Category: Inagaki F]]
-[[Category: Kohda, D.]]
+[[Category: Kohda D]]
-[[Category: Odaka, M.]]
+[[Category: Odaka M]]
-[[Category: Phosphoric diester hydrolase]]