1hle: Difference between revisions

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[[Image:1hle.jpg|left|200px]]


{{Structure
==CRYSTAL STRUCTURE OF CLEAVED EQUINE LEUCOCYTE ELASTASE INHIBITOR DETERMINED AT 1.95 ANGSTROMS RESOLUTION==
|PDB= 1hle |SIZE=350|CAPTION= <scene name='initialview01'>1hle</scene>, resolution 1.95&Aring;
<StructureSection load='1hle' size='340' side='right'caption='[[1hle]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=ACE:ACETYL GROUP'>ACE</scene>
<table><tr><td colspan='2'>[[1hle]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HLE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HLE FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hle FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hle OCA], [https://pdbe.org/1hle PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hle RCSB], [https://www.ebi.ac.uk/pdbsum/1hle PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hle ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ILEU_HORSE ILEU_HORSE] Thought to be involved in the control of intracellular protein turnover.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hl/1hle_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hle ConSurf].
<div style="clear:both"></div>


'''CRYSTAL STRUCTURE OF CLEAVED EQUINE LEUCOCYTE ELASTASE INHIBITOR DETERMINED AT 1.95 ANGSTROMS RESOLUTION'''
==See Also==
 
*[[Serpin 3D structures|Serpin 3D structures]]
 
__TOC__
==Overview==
</StructureSection>
The crystal structure of active-site cleaved equine leucocyte elastase inhibitor, a member of the serpin superfamily, has been solved and refined to a crystallographic R-factor of 17.6% at 1.95 A resolution. Despite being an intracellular inhibitor with rather low sequence homology of 30% to human alpha 1-antichymotrypsin and alpha 1-proteinase inhibitor, the three-dimensional structures are very similar, with deviations only at the sites of insertions and few mobile secondary structure elements. The better resolution in comparison with the structures of other cleaved serpins allows a more precise description of the so-called R-state of the serpins.
 
==About this Structure==
1HLE is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HLE OCA].
 
==Reference==
Crystal structure of cleaved equine leucocyte elastase inhibitor determined at 1.95 A resolution., Baumann U, Bode W, Huber R, Travis J, Potempa J, J Mol Biol. 1992 Aug 20;226(4):1207-18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1518052 1518052]
[[Category: Equus caballus]]
[[Category: Equus caballus]]
[[Category: Protein complex]]
[[Category: Large Structures]]
[[Category: Baumann, U.]]
[[Category: Baumann U]]
[[Category: Bode, W.]]
[[Category: Bode W]]
[[Category: Huber, R.]]
[[Category: Huber R]]
[[Category: Potempa, J.]]
[[Category: Potempa J]]
[[Category: Travis, J.]]
[[Category: Travis J]]
[[Category: ACE]]
[[Category: CA]]
[[Category: hydrolase inhibitor(serine proteinase)]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:38:41 2008''

Latest revision as of 14:32, 27 March 2024

CRYSTAL STRUCTURE OF CLEAVED EQUINE LEUCOCYTE ELASTASE INHIBITOR DETERMINED AT 1.95 ANGSTROMS RESOLUTIONCRYSTAL STRUCTURE OF CLEAVED EQUINE LEUCOCYTE ELASTASE INHIBITOR DETERMINED AT 1.95 ANGSTROMS RESOLUTION

Structural highlights

1hle is a 2 chain structure with sequence from Equus caballus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.95Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ILEU_HORSE Thought to be involved in the control of intracellular protein turnover.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1hle, resolution 1.95Å

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