1he9: Difference between revisions

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-[[Image:1he9.gif|left|200px]]
-<!--
+==Crystal structure of the GAP domain of the Pseudomonas aeruginosa ExoS toxin==
-The line below this paragraph, containing "STRUCTURE_1he9", creates the "Structure Box" on the page.
+<StructureSection load='1he9' size='340' side='right'caption='[[1he9]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1he9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HE9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HE9 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-{{STRUCTURE_1he9|  PDB=1he9  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1he9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1he9 OCA], [https://pdbe.org/1he9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1he9 RCSB], [https://www.ebi.ac.uk/pdbsum/1he9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1he9 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q51451_PSEAI Q51451_PSEAI]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/he/1he9_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1he9 ConSurf].
+<div style="clear:both"></div>
-'''CRYSTAL STRUCTURE OF THE GAP DOMAIN OF THE PSEUDOMONAS AERUGINOSA EXOS TOXIN'''
+==See Also==
+*[[Exoenzyme 3D structures|Exoenzyme 3D structures]]
+__TOC__
-==Overview==
+</StructureSection>
-Pseudomonas aeruginosa is an opportunistic bacterial pathogen of great medical relevance. One of its major toxins, exoenzyme S (ExoS), is a dual function protein with a C-terminal Ras-ADP-ribosylation domain and an N-terminal GTPase activating protein (GAP) domain specific for Rho-family proteins. We report here the three-dimensional structure of the N-terminal domain of ExoS determined by X-ray crystallography to 2.4 A resolution. Its fold is all helical with a four helix bundle core capped by additional irregular helices. Loops that are known to interact with Rho-family proteins show very large mobility. Considering the importance of ExoS in Pseudomonas pathogenicity, this structure could be of interest for drug targeting.
+[[Category: Large Structures]]
-==About this Structure==
-HE9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HE9 OCA].
-==Reference==
-Structure of the ExoS GTPase activating domain., Wurtele M, Renault L, Barbieri JT, Wittinghofer A, Wolf E, FEBS Lett. 2001 Feb 23;491(1-2):26-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11226412 11226412]
-[[Category: Pseudomonas aeruginosa]]
-[[Category: Single protein]]
-[[Category: Barbieri, J T.]]
-[[Category: Renault, L.]]
-[[Category: Wittinghofer, A.]]
-[[Category: Wolf, E.]]
-[[Category: Wurtele, M.]]
-[[Category: Exo]]
-[[Category: Gap]]
 [[Category: Pseudomonas aeruginosa]]
-[[Category: Signal transduction]]
+[[Category: Barbieri JT]]
-[[Category: Toxin]]
+[[Category: Renault L]]
-[[Category: Virulence factor]]
+[[Category: Wittinghofer A]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 18:45:28 2008''
+[[Category: Wolf E]]
+[[Category: Wurtele M]]