1h57: Difference between revisions

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-[[Image:1h57.jpg|left|200px]]
-<!--
+==Structure of horseradish peroxidase C1A compound III==
-The line below this paragraph, containing "STRUCTURE_1h57", creates the "Structure Box" on the page.
+<StructureSection load='1h57' size='340' side='right'caption='[[1h57]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1h57]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Armoracia_rusticana Armoracia rusticana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H57 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H57 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=OXY:OXYGEN+MOLECULE'>OXY</scene>, <scene name='pdbligand=PEO:HYDROGEN+PEROXIDE'>PEO</scene></td></tr>
-{{STRUCTURE_1h57|  PDB=1h57  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h57 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h57 OCA], [https://pdbe.org/1h57 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h57 RCSB], [https://www.ebi.ac.uk/pdbsum/1h57 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h57 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PER1A_ARMRU PER1A_ARMRU] Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h5/1h57_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1h57 ConSurf].
+<div style="clear:both"></div>
-'''STRUCTURE OF HORSERADISH PEROXIDASE C1A COMPOUND III'''
+==See Also==
+*[[Horseradish peroxidase|Horseradish peroxidase]]
+__TOC__
-==Overview==
+</StructureSection>
-A molecular description of oxygen and peroxide activation in biological systems is difficult, because electrons liberated during X-ray data collection reduce the active centres of redox enzymes catalysing these reactions. Here we describe an effective strategy to obtain crystal structures for high-valency redox intermediates and present a three-dimensional movie of the X-ray-driven catalytic reduction of a bound dioxygen species in horseradish peroxidase (HRP). We also describe separate experiments in which high-resolution structures could be obtained for all five oxidation states of HRP, showing such structures with preserved redox states for the first time.
-==About this Structure==
-H57 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Armoracia_rusticana Armoracia rusticana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H57 OCA].
-==Reference==
-The catalytic pathway of horseradish peroxidase at high resolution., Berglund GI, Carlsson GH, Smith AT, Szoke H, Henriksen A, Hajdu J, Nature. 2002 May 23;417(6887):463-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12024218 12024218]
 [[Category: Armoracia rusticana]]
-[[Category: Peroxidase]]
+[[Category: Large Structures]]
-[[Category: Single protein]]
+[[Category: Berglund GI]]
-[[Category: Berglund, G I.]]
+[[Category: Carlsson GH]]
-[[Category: Carlsson, G H.]]
+[[Category: Hajdu J]]
-[[Category: Hajdu, J.]]
-[[Category: Henriksen, A.]]
-[[Category: Smith, A T.]]
-[[Category: Szoke, H.]]
-[[Category: Catalytic intermediate]]
-[[Category: Compound iii]]
-[[Category: Horseradish]]
-[[Category: Oxidoreductase]]
-[[Category: Oxyperoxidase]]
-[[Category: Peroxidase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 18:26:47 2008''