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[[Image:1gzd.gif|left|200px]]<br />
<applet load="1gzd" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1gzd, resolution 2.50&Aring;" />
'''CRYSTAL STRUCTURE OF PIG PHOSPHOGLUCOSE ISOMERASE'''<br />


==About this Structure==
==Crystal structure of pig phosphoglucose isomerase==
1GZD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Glucose-6-phosphate_isomerase Glucose-6-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.9 5.3.1.9] Structure known Active Site: ASB. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GZD OCA].  
<StructureSection load='1gzd' size='340' side='right'caption='[[1gzd]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1gzd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GZD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GZD FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gzd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gzd OCA], [https://pdbe.org/1gzd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gzd RCSB], [https://www.ebi.ac.uk/pdbsum/1gzd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gzd ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/G6PI_PIG G6PI_PIG] Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gz/1gzd_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gzd ConSurf].
<div style="clear:both"></div>


==Reference==
==See Also==
Crystal structure of phosphoglucose isomerase from pig muscle and its complex with 5-phosphoarabinonate., Davies C, Muirhead H, Proteins. 2002 Dec 1;49(4):577-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12402366 12402366]
*[[Phosphoglucose isomerase 3D structures|Phosphoglucose isomerase 3D structures]]
[[Category: Glucose-6-phosphate isomerase]]
__TOC__
[[Category: Single protein]]
</StructureSection>
[[Category: Large Structures]]
[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
[[Category: Davies, C.]]
[[Category: Davies C]]
[[Category: Muirhead, H.]]
[[Category: Muirhead H]]
[[Category: SO4]]
[[Category: aldose-ketose isomerase]]
[[Category: cytokine]]
[[Category: gluconeogenesis]]
[[Category: glycolysis]]
[[Category: glycolytic enzyme]]
[[Category: multifunctional protein]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov  5 12:53:15 2007''

Latest revision as of 14:26, 27 March 2024

Crystal structure of pig phosphoglucose isomeraseCrystal structure of pig phosphoglucose isomerase

Structural highlights

1gzd is a 1 chain structure with sequence from Sus scrofa. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.5Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

G6PI_PIG Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1gzd, resolution 2.50Å

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