1gu2: Difference between revisions

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-[[Image:1gu2.jpg|left|200px]]
-<!--
+==Crystal structure of oxidized cytochrome c'' from Methylophilus methylotrophus==
-The line below this paragraph, containing "STRUCTURE_1gu2", creates the "Structure Box" on the page.
+<StructureSection load='1gu2' size='340' side='right'caption='[[1gu2]], [[Resolution|resolution]] 1.19&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1gu2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Methylophilus_methylotrophus_W3A1 Methylophilus methylotrophus W3A1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GU2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GU2 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.19&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEC:HEME+C'>HEC</scene></td></tr>
-{{STRUCTURE_1gu2|  PDB=1gu2  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gu2 OCA], [https://pdbe.org/1gu2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gu2 RCSB], [https://www.ebi.ac.uk/pdbsum/1gu2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gu2 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CYCA_METME CYCA_METME]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gu/1gu2_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gu2 ConSurf].
+<div style="clear:both"></div>
-'''CRYSTAL STRUCTURE OF OXIDIZED CYTOCHROME C" FROM METHYLOPHILUS METHYLOTROPHUS'''
+==See Also==
+*[[Cytochrome C 3D structures|Cytochrome C 3D structures]]
+__TOC__
-==Overview==
+</StructureSection>
-The crystal structures of the oxidized and reduced forms of cytochrome c" from Methylophilus methylotrophus were solved from X-ray synchrotron data to atomic resolution. The overall fold of the molecule in the two redox states is very similar and is comparable to that of the oxygen-binding protein from the purple phototrophic bacterium Rhodobacter sphaeroides. However, significant modifications occur near the haem group, in particular the detachment from axial binding of His95 observed upon reduction as well as the adoption of different conformations of some protonatable residues that form a possible proton path from the haem pocket to the protein surface. These changes are associated with the previously well characterized redox-Bohr behaviour of this protein. Furthermore they provide a model for one of the presently proposed mechanisms of proton translocation in the much more complex protein cytochrome c oxidase.
+[[Category: Large Structures]]
+[[Category: Methylophilus methylotrophus W3A1]]
-==About this Structure==
+[[Category: Carrondo MA]]
-GU2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methylophilus_methylotrophus Methylophilus methylotrophus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GU2 OCA].
+[[Category: Enguita FJ]]
+[[Category: Pohl E]]
-==Reference==
+[[Category: Rodrigues A]]
-Structural evidence for a proton transfer pathway coupled with haem reduction of cytochrome c" from Methylophilus methylotrophus., Enguita FJ, Pohl E, Turner DL, Santos H, Carrondo MA, J Biol Inorg Chem. 2006 Mar;11(2):189-96. Epub 2005 Dec 10. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16341897 16341897]
+[[Category: Santos H]]
-[[Category: Methylophilus methylotrophus]]
-[[Category: Single protein]]
-[[Category: Carrondo, M A.]]
-[[Category: Enguita, F J.]]
-[[Category: Pohl, E.]]
-[[Category: Rodrigues, A.]]
-[[Category: Santos, H.]]
-[[Category: Electron transport]]
-[[Category: Oxidoreductase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 18:00:26 2008''