1gkf: Difference between revisions

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[[Image:1gkf.png|left|200px]]


{{STRUCTURE_1gkf|  PDB=1gkf  |  SCENE= }}
==Crystal structures of penicillin acylase enzyme-substrate complexes: Structural insights into the catalytic mechanism==
 
<StructureSection load='1gkf' size='340' side='right'caption='[[1gkf]], [[Resolution|resolution]] 1.41&Aring;' scene=''>
===CRYSTAL STRUCTURES OF PENICILLIN ACYLASE ENZYME-SUBSTRATE COMPLEXES: STRUCTURAL INSIGHTS INTO THE CATALYTIC MECHANISM===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1gkf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GKF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GKF FirstGlance]. <br>
{{ABSTRACT_PUBMED_11601852}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.41&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SME:METHIONINE+SULFOXIDE'>SME</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gkf OCA], [https://pdbe.org/1gkf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gkf RCSB], [https://www.ebi.ac.uk/pdbsum/1gkf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gkf ProSAT]</span></td></tr>
[[1gkf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GKF OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/PAC_ECOLX PAC_ECOLX]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gk/1gkf_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gkf ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Penicillin acylase|Penicillin acylase]]
*[[Penicillin acylase|Penicillin acylase]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:011601852</ref><ref group="xtra">PMID:002217137</ref><references group="xtra"/>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Penicillin amidase]]
[[Category: Large Structures]]
[[Category: Brannigan, J A.]]
[[Category: Brannigan JA]]
[[Category: Dodson, G G.]]
[[Category: Dodson GG]]
[[Category: Mcvey, C E.]]
[[Category: McVey CE]]
[[Category: Walsh, M A.]]
[[Category: Walsh MA]]
[[Category: Wilson, K S.]]
[[Category: Wilson KS]]
[[Category: Antibiotic resistance]]

Latest revision as of 14:22, 27 March 2024

Crystal structures of penicillin acylase enzyme-substrate complexes: Structural insights into the catalytic mechanismCrystal structures of penicillin acylase enzyme-substrate complexes: Structural insights into the catalytic mechanism

Structural highlights

1gkf is a 2 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.41Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PAC_ECOLX

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1gkf, resolution 1.41Å

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OCA