1gjw: Difference between revisions

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OCA

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-[[Image:1gjw.gif|left|200px]]<br />
-<applet load="1gjw" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="1gjw, resolution 2.1&Aring;" />
-'''THERMOTOGA MARITIMA MALTOSYLTRANSFERASE COMPLEX WITH MALTOSE'''<br />
-==Overview==
+==Thermotoga maritima maltosyltransferase complex with maltose==
-Maltosyltransferase (MTase) from the hyperthermophile Thermotoga maritima, represents a novel maltodextrin glycosyltransferase acting on starch and, malto-oligosaccharides. It catalyzes the transfer of maltosyl units from, alpha-1,4-linked glucans or malto-oligosaccharides to other, alpha-1,4-linked glucans, malto-oligosaccharides or glucose. It belongs to, the glycoside hydrolase family 13, which represents a large group of, (beta/alpha)(8) barrel proteins sharing a similar active site structure., The crystal structures of MTase and its complex with maltose have been, determined at 2.4 A and 2.1 A resolution, respectively. MTase is a, homodimer, each subunit of which consists of four domains, two of which, are structurally homologous to those of other family 13 enzymes. The, catalytic ... [[http://ispc.weizmann.ac.il/pmbin/getpm?11545590 (full description)]]
+<StructureSection load='1gjw' size='340' side='right'caption='[[1gjw]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1gjw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima_MSB8 Thermotoga maritima MSB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GJW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GJW FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=PRD_900001:alpha-maltose'>PRD_900001</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gjw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gjw OCA], [https://pdbe.org/1gjw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gjw RCSB], [https://www.ebi.ac.uk/pdbsum/1gjw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gjw ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/O33838_THEMT O33838_THEMT]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gj/1gjw_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gjw ConSurf].
+<div style="clear:both"></div>
-==About this Structure==
+==See Also==
-GJW is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]] with MAL, GLC and PO4 as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GJW OCA]].
+*[[Glycosyltransferase 3D structures|Glycosyltransferase 3D structures]]
+__TOC__
-==Reference==
+</StructureSection>
-The crystal structure of Thermotoga maritima maltosyltransferase and its implications for the molecular basis of the novel transfer specificity., Roujeinikova A, Raasch C, Burke J, Baker PJ, Liebl W, Rice DW, J Mol Biol. 2001 Sep 7;312(1):119-31. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11545590 11545590]
+[[Category: Large Structures]]
-[[Category: Single protein]]
+[[Category: Thermotoga maritima MSB8]]
-[[Category: Thermotoga maritima]]
+[[Category: Baker PJ]]
-[[Category: Baker, P.J.]]
+[[Category: Burke J]]
-[[Category: Burke, J.]]
+[[Category: Liebl W]]
-[[Category: Liebl, W.]]
+[[Category: Raasch C]]
-[[Category: Raasch, C.]]
+[[Category: Rice DW]]
-[[Category: Rice, D.W.]]
+[[Category: Roujeinikova A]]
-[[Category: Roujeinikova, A.]]
-[[Category: GLC]]
-[[Category: MAL]]
-[[Category: PO4]]
-[[Category: alpha-amylase]]
-[[Category: maltosyltransferase]]
-[[Category: transferase]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 20:33:09 2007''