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[[Image:1g6r.gif|left|200px]]<br /><applet load="1g6r" size="350" color="white" frame="true" align="right" spinBox="true"
caption="1g6r, resolution 2.8&Aring;" />
'''A FUNCTIONAL HOT SPOT FOR ANTIGEN RECOGNITION IN A SUPERAGONIST TCR/MHC COMPLEX'''<br />


==Overview==
==A FUNCTIONAL HOT SPOT FOR ANTIGEN RECOGNITION IN A SUPERAGONIST TCR/MHC COMPLEX==
A longstanding question in T cell receptor signaling is how structurally similar ligands, with similar affinities, can have substantially different biological activity. The crystal structure of the 2C TCR complex of H-2Kb with superagonist peptide SIYR at 2.8 A elucidates a structural basis for TCR discrimination of altered peptide ligands. The difference in antigen potency is modulated by two cavities in the TCR combining site, formed mainly by CDRs 3alpha, 3beta, and 1beta, that complement centrally located peptide residues. This "functional hot spot" allows the TCR to finely discriminate amongst energetically similar interactions within different ligands for those in which the peptide appropriately stabilizes the TCR/pMHC complex and provides a new structural perspective for understanding differential signaling resulting from T cell cross-reactivity.
<StructureSection load='1g6r' size='340' side='right'caption='[[1g6r]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1g6r]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G6R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1G6R FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1g6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g6r OCA], [https://pdbe.org/1g6r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1g6r RCSB], [https://www.ebi.ac.uk/pdbsum/1g6r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1g6r ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TVA1_MOUSE TVA1_MOUSE]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g6/1g6r_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1g6r ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
1G6R is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G6R OCA].
*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
 
*[[MHC 3D structures|MHC 3D structures]]
==Reference==
*[[MHC I 3D structures|MHC I 3D structures]]
A functional hot spot for antigen recognition in a superagonist TCR/MHC complex., Degano M, Garcia KC, Apostolopoulos V, Rudolph MG, Teyton L, Wilson IA, Immunity. 2000 Mar;12(3):251-61. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10755612 10755612]
*[[T-cell receptor 3D structures|T-cell receptor 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Protein complex]]
[[Category: Apostolopoulos V]]
[[Category: Apostolopoulos, V.]]
[[Category: Degano M]]
[[Category: Degano, M.]]
[[Category: Garcia KC]]
[[Category: Garcia, K C.]]
[[Category: Rudolph MG]]
[[Category: Rudolph, M G.]]
[[Category: Teyton L]]
[[Category: Teyton, L.]]
[[Category: Wilson IA]]
[[Category: Wilson, I A.]]
[[Category: major histocompatibility complex]]
[[Category: superagonist]]
[[Category: t cell antigen receptor]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:46:42 2008''

Latest revision as of 14:19, 27 March 2024

A FUNCTIONAL HOT SPOT FOR ANTIGEN RECOGNITION IN A SUPERAGONIST TCR/MHC COMPLEXA FUNCTIONAL HOT SPOT FOR ANTIGEN RECOGNITION IN A SUPERAGONIST TCR/MHC COMPLEX

Structural highlights

1g6r is a 10 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.8Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TVA1_MOUSE

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1g6r, resolution 2.80Å

Drag the structure with the mouse to rotate

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