1fj8: Difference between revisions

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-{{Seed}}
-[[Image:1fj8.png|left|200px]]
-<!--
+==THE STRUCTURE OF BETA-KETOACYL-[ACYL CARRIER PROTEIN] SYNTHASE I IN COMPLEX WITH CERULENIN, IMPLICATIONS FOR DRUG DESIGN==
-The line below this paragraph, containing "STRUCTURE_1fj8", creates the "Structure Box" on the page.
+<StructureSection load='1fj8' size='340' side='right'caption='[[1fj8]], [[Resolution|resolution]] 2.27&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1fj8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FJ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FJ8 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.27&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CER:(2S,+3R)-3-HYDROXY-4-OXO-7,10-TRANS,TRANS-DODECADIENAMIDE'>CER</scene></td></tr>
-{{STRUCTURE_1fj8|  PDB=1fj8  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fj8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fj8 OCA], [https://pdbe.org/1fj8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fj8 RCSB], [https://www.ebi.ac.uk/pdbsum/1fj8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fj8 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/FABB_ECOLI FABB_ECOLI] Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fj/1fj8_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fj8 ConSurf].
+<div style="clear:both"></div>
-===THE STRUCTURE OF BETA-KETOACYL-[ACYL CARRIER PROTEIN] SYNTHASE I IN COMPLEX WITH CERULENIN, IMPLICATIONS FOR DRUG DESIGN===
+==See Also==
+*[[Acyl carrier protein synthase 3D structures|Acyl carrier protein synthase 3D structures]]
+__TOC__
-<!--
+</StructureSection>
-The line below this paragraph, {{ABSTRACT_PUBMED_11050088}}, adds the Publication Abstract to the page
-(as it appears on PubMed at http://www.pubmed.gov), where 11050088 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_11050088}}
-==About this Structure==
-FJ8 is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FJ8 OCA].
-==Reference==
-<ref group="xtra">PMID:11050088</ref><references group="xtra"/>
-[[Category: Beta-ketoacyl-acyl-carrier-protein synthase I]]
 [[Category: Escherichia coli]]
-[[Category: Choi, K.]]
+[[Category: Large Structures]]
-[[Category: Heath, R J.]]
+[[Category: Choi K]]
-[[Category: Li, Z.]]
+[[Category: Heath RJ]]
-[[Category: Price, A C.]]
+[[Category: Li Z]]
-[[Category: Rock, C O.]]
+[[Category: Price AC]]
-[[Category: White, S W.]]
+[[Category: Rock CO]]
-[[Category: Cerulenin]]
+[[Category: White SW]]
-[[Category: Condensing enzyme]]
-[[Category: Drug design]]
-[[Category: Fatty acid elongation]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 11:50:19 2009''