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==== | ==Bovine 20S immunoproteasome in complex with two human PA28alpha-beta activators== | ||
<StructureSection load='7drw' size='340' side='right'caption='[[7drw]]' scene=''> | <StructureSection load='7drw' size='340' side='right'caption='[[7drw]], [[Resolution|resolution]] 4.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | <table><tr><td colspan='2'>[[7drw]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DRW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DRW FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7drw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7drw OCA], [https://pdbe.org/7drw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7drw RCSB], [https://www.ebi.ac.uk/pdbsum/7drw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7drw ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.2Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7drw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7drw OCA], [https://pdbe.org/7drw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7drw RCSB], [https://www.ebi.ac.uk/pdbsum/7drw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7drw ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/PSA6_BOVIN PSA6_BOVIN] Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).[UniProtKB:P60900] | |||
==See Also== | |||
*[[Proteasome 3D structures|Proteasome 3D structures]] | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Bos taurus]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Cong Y]] | ||
[[Category: Xu C]] | |||
Latest revision as of 13:54, 27 March 2024
Bovine 20S immunoproteasome in complex with two human PA28alpha-beta activatorsBovine 20S immunoproteasome in complex with two human PA28alpha-beta activators
Structural highlights
FunctionPSA6_BOVIN Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).[UniProtKB:P60900] See Also |
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