7da4: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Unreleased structure'''
-The entry 7da4 is ON HOLD
+==Cryo-EM structure of amyloid fibril formed by human RIPK3==
+<StructureSection load='7da4' size='340' side='right'caption='[[7da4]], [[Resolution|resolution]] 4.24&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7da4]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DA4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DA4 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.24&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7da4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7da4 OCA], [https://pdbe.org/7da4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7da4 RCSB], [https://www.ebi.ac.uk/pdbsum/7da4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7da4 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/RIPK3_HUMAN RIPK3_HUMAN] Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.<ref>PMID:19498109</ref> <ref>PMID:19524512</ref> <ref>PMID:19524513</ref> <ref>PMID:22265413</ref> <ref>PMID:22265414</ref> <ref>PMID:22421439</ref>
-Authors: Zhao, K., Ma, Y.Y., Sun, Y.P., Li, D., Liu, C.
+==See Also==
+*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
-Description: Cryo-EM structure of amyloid fibril formed by human RIPK3
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Liu, C]]
+__TOC__
-[[Category: Zhao, K]]
+</StructureSection>
-[[Category: Li, D]]
+[[Category: Homo sapiens]]
-[[Category: Sun, Y.P]]
+[[Category: Large Structures]]
-[[Category: Ma, Y.Y]]
+[[Category: Li D]]
+[[Category: Liu C]]
+[[Category: Ma YY]]
+[[Category: Sun YP]]
+[[Category: Zhao K]]