7d6e: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==Structural insights into membrane remodeling by SNX1== | ==Structural insights into membrane remodeling by SNX1== | ||
<StructureSection load='7d6e' size='340' side='right'caption='[[7d6e]]' scene=''> | <StructureSection load='7d6e' size='340' side='right'caption='[[7d6e]], [[Resolution|resolution]] 10.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7D6E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7D6E FirstGlance]. <br> | <table><tr><td colspan='2'>[[7d6e]] is a 18 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7D6E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7D6E FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7d6e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7d6e OCA], [https://pdbe.org/7d6e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7d6e RCSB], [https://www.ebi.ac.uk/pdbsum/7d6e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7d6e ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 10Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7d6e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7d6e OCA], [https://pdbe.org/7d6e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7d6e RCSB], [https://www.ebi.ac.uk/pdbsum/7d6e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7d6e ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/SNX1_MOUSE SNX1_MOUSE] Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity. Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1). Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R. Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN. Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking (By similarity).[UniProtKB:Q13596] | |||
==See Also== | |||
*[[Sorting nexin 3D structures|Sorting nexin 3D structures]] | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Mus musculus]] | |||
[[Category: Pang X]] | [[Category: Pang X]] | ||
[[Category: Sun F]] | [[Category: Sun F]] | ||
[[Category: Zhang Y]] | [[Category: Zhang Y]] | ||