7d6e: Difference between revisions

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-'''Unreleased structure'''
-The entry 7d6e is ON HOLD  until Paper Publication
+==Structural insights into membrane remodeling by SNX1==
+<StructureSection load='7d6e' size='340' side='right'caption='[[7d6e]], [[Resolution|resolution]] 10.00&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7d6e]] is a 18 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7D6E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7D6E FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 10&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7d6e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7d6e OCA], [https://pdbe.org/7d6e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7d6e RCSB], [https://www.ebi.ac.uk/pdbsum/7d6e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7d6e ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/SNX1_MOUSE SNX1_MOUSE] Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity. Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1). Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R. Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN. Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking (By similarity).[UniProtKB:Q13596]
-Authors: Zhang, Y., Pang, X., Sun, F.
+==See Also==
+*[[Sorting nexin 3D structures|Sorting nexin 3D structures]]
-Description: Structural insights into membrane remodeling by SNX1
+__TOC__
-[[Category: Unreleased Structures]]
+</StructureSection>
-[[Category: Pang, X]]
+[[Category: Large Structures]]
-[[Category: Zhang, Y]]
+[[Category: Mus musculus]]
-[[Category: Sun, F]]
+[[Category: Pang X]]
+[[Category: Sun F]]
+[[Category: Zhang Y]]