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==Cryo-EM structure of yeast Ribonuclease MRP with substrate ITS1==
==Cryo-EM structure of yeast Ribonuclease MRP with substrate ITS1==
<StructureSection load='7c7a' size='340' side='right'caption='[[7c7a]]' scene=''>
<StructureSection load='7c7a' size='340' side='right'caption='[[7c7a]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7C7A OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7C7A FirstGlance]. <br>
<table><tr><td colspan='2'>[[7c7a]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7C7A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7C7A FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7c7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7c7a OCA], [http://pdbe.org/7c7a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7c7a RCSB], [http://www.ebi.ac.uk/pdbsum/7c7a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7c7a ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7c7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7c7a OCA], [https://pdbe.org/7c7a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7c7a RCSB], [https://www.ebi.ac.uk/pdbsum/7c7a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7c7a ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/POP1_YEAST POP1_YEAST] Required for processing of 5.8S rRNA (short form) at site A3 and for 5' and 3' processing of pre-tRNA.<ref>PMID:7926742</ref> <ref>PMID:9620854</ref>
==See Also==
*[[Ribonuclease 3D structures|Ribonuclease 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Lan P]]
[[Category: Lan P]]
[[Category: Lei M]]
[[Category: Lei M]]
[[Category: Wu J]]
[[Category: Wu J]]

Latest revision as of 13:50, 27 March 2024

Cryo-EM structure of yeast Ribonuclease MRP with substrate ITS1Cryo-EM structure of yeast Ribonuclease MRP with substrate ITS1

Structural highlights

7c7a is a 11 chain structure with sequence from Saccharomyces cerevisiae S288C. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Electron Microscopy, Resolution 2.8Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

POP1_YEAST Required for processing of 5.8S rRNA (short form) at site A3 and for 5' and 3' processing of pre-tRNA.[1] [2]

See Also

References

  1. ↑ Lygerou Z, Mitchell P, Petfalski E, Seraphin B, Tollervey D. The POP1 gene encodes a protein component common to the RNase MRP and RNase P ribonucleoproteins. Genes Dev. 1994 Jun 15;8(12):1423-33. PMID:7926742
  2. ↑ Chamberlain JR, Lee Y, Lane WS, Engelke DR. Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP. Genes Dev. 1998 Jun 1;12(11):1678-90. PMID:9620854

7c7a, resolution 2.80Å

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