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==Cryo-EM structure of Dengue virus serotype 2 complexed with Fab SIgN-3C at pH 5.0== | ==Cryo-EM structure of Dengue virus serotype 2 complexed with Fab SIgN-3C at pH 5.0== | ||
<StructureSection load='7bue' size='340' side='right'caption='[[7bue]]' scene=''> | <StructureSection load='7bue' size='340' side='right'caption='[[7bue]], [[Resolution|resolution]] 7.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BUE OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[7bue]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BUE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BUE FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 7.8Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bue FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bue OCA], [https://pdbe.org/7bue PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bue RCSB], [https://www.ebi.ac.uk/pdbsum/7bue PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bue ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/E0WXJ2_9FLAV E0WXJ2_9FLAV] Component of the viral RNA replication complex that functions in virion assembly and antagonizes the host immune response.[ARBA:ARBA00024317] Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.[ARBA:ARBA00003504] Serine protease subunit NS2B: Required cofactor for the serine protease function of NS3.[PROSITE-ProRule:PRU00859] | |||
==See Also== | |||
*[[Antibody 3D structures|Antibody 3D structures]] | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Dengue virus 2]] | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Chew SV]] | [[Category: Chew SV]] | ||
Latest revision as of 13:49, 27 March 2024
Cryo-EM structure of Dengue virus serotype 2 complexed with Fab SIgN-3C at pH 5.0Cryo-EM structure of Dengue virus serotype 2 complexed with Fab SIgN-3C at pH 5.0
Structural highlights
FunctionE0WXJ2_9FLAV Component of the viral RNA replication complex that functions in virion assembly and antagonizes the host immune response.[ARBA:ARBA00024317] Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.[ARBA:ARBA00003504] Serine protease subunit NS2B: Required cofactor for the serine protease function of NS3.[PROSITE-ProRule:PRU00859] See Also |
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