6klq: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older edit
No edit summary
No edit summary
 
(3 intermediate revisions by the same user not shown)
Line 1: Line 1:


==Tropomyosin of cardiac thin filament in high-calcium state==
==Tropomyosin of cardiac thin filament in high-calcium state==
<StructureSection load='6klq' size='340' side='right'caption='[[6klq]], [[Resolution|resolution]] 7.70&Aring;' scene=''>
<SX load='6klq' size='340' side='right' viewer='molstar' caption='[[6klq]], [[Resolution|resolution]] 7.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6klq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KLQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6KLQ FirstGlance]. <br>
<table><tr><td colspan='2'>[[6klq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KLQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6KLQ FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 7.7&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6klq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6klq OCA], [http://pdbe.org/6klq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6klq RCSB], [http://www.ebi.ac.uk/pdbsum/6klq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6klq ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6klq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6klq OCA], [https://pdbe.org/6klq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6klq RCSB], [https://www.ebi.ac.uk/pdbsum/6klq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6klq ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Troponin is an essential component of striated muscle and it regulates the sliding of actomyosin system in a calcium-dependent manner. Despite its importance, the structure of troponin has been elusive due to its high structural heterogeneity. In this study, we analyzed the 3D structures of murine cardiac thin filaments using a cryo-electron microscope equipped with a Volta phase plate (VPP). Contrast enhancement by a VPP enabled us to reconstruct the entire repeat of the thin filament. We determined the orientation of troponin relative to F-actin and tropomyosin, and characterized the interactions between troponin and tropomyosin. This study provides a structural basis for understanding the molecular mechanism of actomyosin system.


Cryo-EM structures of cardiac thin filaments reveal the 3D architecture of troponin.,Oda T, Yanagisawa H, Wakabayashi T J Struct Biol. 2020 Jan 16:107450. doi: 10.1016/j.jsb.2020.107450. PMID:31954841<ref>PMID:31954841</ref>
==See Also==
 
*[[Tropomyosin 3D structures|Tropomyosin 3D structures]]
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6klq" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</SX>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Oda, T]]
[[Category: Oda T]]
[[Category: Wakabayashi, T]]
[[Category: Wakabayashi T]]
[[Category: Yanagisawa, H]]
[[Category: Yanagisawa H]]
[[Category: Cardiac thin filament]]
[[Category: Contractile protein]]

Latest revision as of 13:43, 27 March 2024

Tropomyosin of cardiac thin filament in high-calcium stateTropomyosin of cardiac thin filament in high-calcium state

6klq, resolution 7.70Å

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=6klq&oldid=4113010"