6jb7: Difference between revisions

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-'''Unreleased structure'''
-The entry 6jb7 is ON HOLD
+==Crystal structure of Ub-conjugated Ube2K C92K&K97A mutant (isopeptide linkage), 2.1 A resolution==
+<StructureSection load='6jb7' size='340' side='right'caption='[[6jb7]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6jb7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JB7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JB7 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jb7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jb7 OCA], [https://pdbe.org/6jb7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jb7 RCSB], [https://www.ebi.ac.uk/pdbsum/6jb7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jb7 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/UBE2K_HUMAN UBE2K_HUMAN] Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein-dependent degradation of RB1.<ref>PMID:8702625</ref> <ref>PMID:10634809</ref> <ref>PMID:10675012</ref> <ref>PMID:16714285</ref> <ref>PMID:16868077</ref> <ref>PMID:17873885</ref> <ref>PMID:20061386</ref> <ref>PMID:19906396</ref>
-Authors: Lee, J.-G., Youn, H.-S., Lee, Y., An, J.Y., Park, K.R., Kang, J.Y., Mun, S.A., Park, J., Park, T., Jin, M.W., Yang, J., Eom, S.H.
+==See Also==
+*[[3D structures of ubiquitin|3D structures of ubiquitin]]
-Description: Crystal structure of Ub-conjugated Ube2K C92K&K97A mutant (isopeptide linkage), 2.1 A resolution
+*[[3D structures of ubiquitin conjugating enzyme|3D structures of ubiquitin conjugating enzyme]]
-[[Category: Unreleased Structures]]
+== References ==
-[[Category: An, J.Y]]
+<references/>
-[[Category: Youn, H.-S]]
+__TOC__
-[[Category: Park, T]]
+</StructureSection>
-[[Category: Park, K.R]]
+[[Category: Homo sapiens]]
-[[Category: Mun, S.A]]
+[[Category: Large Structures]]
-[[Category: Kang, J.Y]]
+[[Category: An JY]]
-[[Category: Yang, J]]
+[[Category: Eom SH]]
-[[Category: Park, J]]
+[[Category: Jin MW]]
-[[Category: Lee, J.-G]]
+[[Category: Kang JY]]
-[[Category: Lee, Y]]
+[[Category: Lee J-G]]
-[[Category: Eom, S.H]]
+[[Category: Lee Y]]
-[[Category: Jin, M.W]]
+[[Category: Mun SA]]
+[[Category: Park J]]
+[[Category: Park KR]]
+[[Category: Park T]]
+[[Category: Yang J]]
+[[Category: Youn H-S]]